Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance [PDF]
Antibiotics, 2022 The disposal of antibiotics in the aquatic environment favors the selection of bacteria exhibiting antibiotic resistance mechanisms. Quinolones are bactericidal antimicrobials extensively used in both human and animal medicine.
Claudio D. Miranda +3 more
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Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance [PDF]
Frontiers in Microbiology, 2023 Quinolone resistance presents a growing global health threat. We employed word-based GWAS to explore genomic data, aiming to enhance our understanding of this phenomenon.
Negin Malekian +5 more
doaj +3 more sources
Quinolone Resistance Genes and Their Contribution to Resistance in Vibrio cholerae Serogroup O139 [PDF]
Antibiotics, 2023 Background. Quinolones are commonly used for reducing the duration of diarrhea, infection severity, and limiting further transmission of disease related to Vibrio cholerae, but V. cholerae susceptibility to quinolone decreases over time.
Yan-Yan Zhou +6 more
doaj +3 more sources
International Journal of Microbiology, 2021 Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged.
Shaymaa H. Abdel-Rhman +2 more
doaj +2 more sources
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars [PDF]
Antibiotics, 2021 Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and
Aqsa Shaheen +6 more
doaj +2 more sources
Plasmid-Mediated Quinolone Resistance Genes in Escherichia coli Strains Isolated from Healthy Dogs [PDF]
Veterinary SciencesKnowledge about the potential roles of pets as reservoirs for plasmid-mediated quinolone resistance is still limited in Türkiye. Thus, in our study, the presence of plasmid-mediated quinolone genes (qnrA, qnrB and qnrS) was examined by multiplex ...
Fatma Kalaycı-Yüksek +4 more
doaj +2 more sources
Prevalence of plasmid-mediated quinolone resistance genes and biofilm formation in different species of quinolone-resistant clinical Shigella isolates: a cross-sectional study [PDF]
European Journal of Medical ResearchBackground The purpose of this study was to look into the presence of plasmid-mediated quinolone resistance (PMQR) genes and biofilm formation in several species of clinical Shigella isolates that were resistant to quinolones.
Noor S. K. Al-Khafaji +9 more
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Journal of Pure and Applied Microbiology, 2022 Klebsiella pneumoniae (K. pneumoniae) is an important pathogen associated with various infections. The emergence of antibiotic resistances, such as quinolone resistance and those due to extended-spectrum beta-lactamases (ESBL), reduces the available ...
Marwah M. Bakri
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2023 : Objectives: The study aimed to characterize the quinolone resistance of Salmonella enterica serovar Typhimurium and its monophasic variant (Salmonella enterica serovar 1,4,[5],12:i:-) isolated from food and patients in China.
Xiaojuan Yang +12 more
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DNA Gyrase as a Target for Quinolones
Biomedicines, 2023 Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA gyrase is one of the primary targets of quinolones, broad-spectrum
Angela C. Spencer, Siva S. Panda
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