Results 1 to 10 of about 2,195,251 (142)

Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance

Antibiotics, 2022
The disposal of antibiotics in the aquatic environment favors the selection of bacteria exhibiting antibiotic resistance mechanisms. Quinolones are bactericidal antimicrobials extensively used in both human and animal medicine.
Claudio D. Miranda, Christopher Concha, Félix A. Godoy, Matthew R. Lee   +3 more
doaj   +2 more sources

Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt

International Journal of Microbiology, 2021
Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged.
Shaymaa H. Abdel-Rhman, Rehab M. Elbargisy, Dina E. Rizk   +2 more
doaj   +2 more sources

Study of Plasmid-Mediated Quinolone Resistance in Klebsiella pneumoniae: Relation to Extended-Spectrum Beta-Lactamases

Journal of Pure and Applied Microbiology, 2022
Klebsiella pneumoniae (K. pneumoniae) is an important pathogen associated with various infections. The emergence of antibiotic resistances, such as quinolone resistance and those due to extended-spectrum beta-lactamases (ESBL), reduces the available ...
Marwah M. Bakri
doaj   +1 more source

Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars

Antibiotics, 2021
Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and
Aqsa Shaheen, Anam Tariq, Mazhar Iqbal, Osman Mirza, Abdul Haque, Thomas Walz, Moazur Rahman   +6 more
doaj   +1 more source

Characterization of quinolone resistance in Salmonella enterica serovar Typhimurium and its monophasic variants from food and patients in China

Journal of Global Antimicrobial Resistance, 2023
: Objectives: The study aimed to characterize the quinolone resistance of Salmonella enterica serovar Typhimurium and its monophasic variant (Salmonella enterica serovar 1,4,[5],12:i:-) isolated from food and patients in China.
Xiaojuan Yang, Shiyuan Yang, Shengrong Liu, Shuxiang Liu, Jumei Zhang, Weipeng Guo, Juan Wang, Zhongjian Song, Liang Xue, Moutong Chen, Shi Wu, Xianhu Wei, Qingping Wu   +12 more
doaj   +1 more source

DNA Gyrase as a Target for Quinolones

Biomedicines, 2023
Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA gyrase is one of the primary targets of quinolones, broad-spectrum
Angela C. Spencer, Siva S. Panda
doaj   +1 more source

Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance

Frontiers in Microbiology, 2023
Quinolone resistance presents a growing global health threat. We employed word-based GWAS to explore genomic data, aiming to enhance our understanding of this phenomenon.
Negin Malekian, Srividhya Sainath, Ali Al-Fatlawi, Ali Al-Fatlawi, Michael Schroeder, Michael Schroeder   +5 more
doaj   +1 more source

Detection of S83V GyrA mutation in quinolone-resistant Shewanella algae using comparative genomics

Journal of Microbiology, Immunology and Infection, 2021
Background: Shewanella algae is a zoonotic pathogen that poses a serious health threat to immunocompromised hosts. Treatment of S. algae infections is challenging due to the pathogen's intrinsic resistance to a variety of β-lactam antibiotics ...
Chien-Hao Tseng, Jan-Fang Cheng, Shi-Yu Chen, Wen-Huei Chen, Zhi-Yuan Shi, Yu-Hui Lin, Che-An Tsai, Shih-Ping Lin, Yung-Chun Chen, Yu-Chia Lin, Yao-Ting Huang, Po-Yu Liu   +11 more
doaj   +1 more source

Emerging coexistence of three PMQR genes on a multiple resistance plasmid with a new surrounding genetic structure of qnrS2 in E. coli in China

Antimicrobial Resistance and Infection Control, 2020
Background Quinolones are commonly used for treatment of infections by bacteria of the Enterobacteriaceae family. However, the rising resistance to quinolones worldwide poses a major clinical and public health risk.
Ying Tao, Kaixin Zhou, Lianyan Xie, Yanping Xu, Lizhong Han, Yuxing Ni, Jieming Qu, Jingyong Sun   +7 more
doaj   +1 more source

High-Level Quinolone-Resistant Haemophilus haemolyticus in Pediatric Patient with No History of Quinolone Exposure

Emerging Infectious Diseases, 2022
The prevalence of antimicrobial resistance among Haemophilus spp. is a critical concern, but high-level quinolone-resistant strains had not been isolated from children. We isolated high-level quinolone-resistant H.
Emi Tanaka, Yuji Hirai, Takeaki Wajima, Yu Ishida, Yoshiaki Kawamura, Hidemasa Nakaminami   +5 more
doaj   +1 more source