DNA Gyrase as a Target for Quinolones [PDF]
Biomedicines, 2023 Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA gyrase is one of the primary targets of quinolones, broad-spectrum
Angela C. Spencer, Siva S. Panda
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The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis. [PDF]
Adv Sci (Weinh)Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Fries F +25 more
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Rapid, DNA-induced interface swapping by DNA gyrase [PDF]
eLifeDNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the active complex.
Thomas RM Germe +5 more
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Design, synthesis, and antibacterial assessment of a new series of ciprofloxacin-based compounds as possible dual DNA gyrase/topoisomerase IV inhibitors [PDF]
Scientific ReportsSimultaneous inhibition of DNA gyrase and topoisomerase IV (Topo IV) is a primary pharmacological strategy to enhance antibacterial efficacy and markedly reduce the emergence of antibiotic resistance.
Lamya H. Al-Wahaibi +4 more
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Friend or Foe: Protein Inhibitors of DNA Gyrase [PDF]
BiologyDNA gyrase is essential for the successful replication of circular chromosomes, such as those found in most bacterial species, by relieving topological stressors associated with unwinding the double-stranded genetic material.
Shengfeng Ruan +2 more
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Insights into antibacterial design: Computational modeling of eugenol derivatives targeting DNA gyrase [PDF]
HeliyonThe rise of antibiotic resistance underscores the urgent need for novel antibacterial agents. DNA gyrase, an essential enzyme involved in bacterial DNA replication, is a promising target for antibacterial therapy.
Heba S. Elsewedy +9 more
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Investigating Escherichia coli Colicin E9 immunity protein interactions with DNA gyrase of Pseudomonas aeruginosa: advanced computational approach for developing novel antimicrobial strategies [PDF]
Scientific ReportsProtein-protein interactions (PPIs) are essential to numerous cellular processes, making a thorough investigation of these interactions crucial for a deeper understanding of molecular mechanisms.
Rihaf Alfaraj +2 more
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In vitro and in silico characterization of Crocatin A from red betel leaves: targeting DNA gyrase B and DNA ligase of Enterococcus faecalis with ADMET-based druglikeness analysis [PDF]
BMC ChemistryDental caries is a disease of tooth tissue that can lead to complications, with Enterococcus faecalis being one of the Gram-positive bacteria that plays a crucial role in the infection process.
Devi Meliani +2 more
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Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase [PDF]
iScienceSummary: Antimicrobial resistance remains a persistent and pressing public health concern. Here, we describe the synthesis of original triazole-containing inhibitors targeting the DNA gyrase, a well-validated drug target for developing new antibiotics ...
Antoine Gedeon +19 more
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Discovery of new Schiff bases of the disalicylic acid scaffold as DNA gyrase and topoisomerase IV inhibitors endowed with antibacterial properties [PDF]
Frontiers in ChemistryDNA gyrase and topoisomerase IV show great potential as targets for antibacterial medicines. In recent decades, various categories of small molecule inhibitors have been identified; however, none have been effective in the market.
Lamya H. Al-Wahaibi +8 more
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