Results 31 to 40 of about 19,626 (172)
DNA binding and antigenic specifications of DNA gyrase [PDF]
Nucleic Acids Research, 1984 Complexes of DNA gyrase and minichromosomal DNA containing the origin of replication of Escherichia coli (oriC) can be formed without metabolic energy and visualised by electron microscopy. The A subunit, part of the A2B2-DNA gyrase complex is the binding protein. Various binding sites are scattered around the minichromosomal DNA including oriC.
H, Lother, R, Lurz, E, Orr
openaire +2 more sources
Synthesis, In Silico and In Vitro Antimicrobial Evaluation of Cyanoketene S,N-Acetals and their Pyrazoles Against Staphylococcus aureus DNA Gyrase Enzyme [PDF]
Journal of Advanced Pharmacy Research, 2021 Objectives: The continuous reporting of bacterial resistance to antibiotics is an ongoing challenge that can be life-threatening. Actions to develop new chemicals to overcome the bacterial resistance has gained a significant importance. Methods: A series
Ashraf Hassan +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2019 Drug tolerance in mycobacterial pathogens is a global concern. Fluoroquinolone (FQ) treatment is widely used for induction of persisters in bacteria.
Eira Choudhary +4 more
doaj +1 more source
Microbiology Spectrum, 2022 The aminobenzimidazole SPR719 targets DNA gyrase in Mycobacterium tuberculosis. The molecule acts as inhibitor of the enzyme’s ATPase located on the Gyrase B subunit of the tetrameric Gyrase A2B2 protein.
Wassihun Wedajo Aragaw +6 more
doaj +1 more source
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.
PLoS Genetics, 2020 DNA supercoiling is essential for all living cells because it controls all processes involving DNA. In bacteria, global DNA supercoiling results from the opposing activities of topoisomerase I, which relaxes DNA, and DNA gyrase, which compacts DNA. These
Alexandre Duprey, Eduardo A Groisman
doaj +1 more source
Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.
PLoS ONE, 2010 BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts +4 more
doaj +1 more source
In silico analysis of ciprofloxacin analogs as inhibitors of DNA gyrase of Staphylococcus aureus
Informatics in Medicine Unlocked, 2021 In this in silico study, thirty-five ciprofloxacin analogs were docked to the active site of DNA gyrase, the prime target of ciprofloxacin type antibiotics. Prior to docking all the structures were optimized using MM2 force field parameters.
Md. Rakhibul Hasan +7 more
doaj +1 more source
Advanced Science, EarlyView.The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen +9 more
wiley +1 more source
Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
Nature Communications, 2019 Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-
Arnaud Vanden Broeck +3 more
doaj +1 more source
International Journal of Medical Microbiology, 2020 Allicin (diallylthiosulfinate) is a potent antimicrobial substance, produced by garlic tissues upon wounding as a defence against pathogens and pests.
Jana Reiter +4 more
doaj +1 more source