Results 31 to 40 of about 1,477,235 (156)

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases [PDF]

, 2010
ype II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA replication, recombination and transcription. They change DNA topology by forming a transient covalent cleavage complex with a gate-DNA duplex that allows transport of a ...
Laponogov, I, Fisher L. Mark, Pan, Xiao-Su, Sanderson, MR, Xiao-Su Pan, Katherine E McAuley, Fisher, LM, McAuley, Katherine E., McAuley, KE, Pan Xiao-Su, Veselkov, Dennis A., Ivan Laponogov, Mark R. Sanderson, Veselkov Dennis A., Sanderson Mark R., L Mark Fisher, Veselkov, DA, Mark R Sanderson, Fisher, L. Mark, Dennis A. Veselkov, Katherine E. McAuley, Laponogov Ivan, Sanderson, Mark R., Laponogov, Ivan, McAuley Katherine E., Dennis A Veselkov, Pan, XS, L. Mark Fisher   +27 more
core   +1 more source

PprA Protein Is Involved in Chromosome Segregation via Its Physical and Functional Interaction with DNA Gyrase in Irradiated Deinococcus radiodurans Bacteria

mSphere, 2016
PprA, a radiation-induced Deinococcus-specific protein, was previously shown to be required for cell survival and accurate chromosome segregation after exposure to ionizing radiation. Here, we used an in vivo approach to determine, by shotgun proteomics,
Alice Devigne, Philippe Guérin, Johnny Lisboa, Sophie Quevillon-Cheruel, Jean Armengaud, Suzanne Sommer, Claire Bouthier de la Tour, Pascale Servant   +7 more
doaj   +1 more source

Design and synthesis of new 3-((7-chloroquinolin-4-yl)amino)thiazolidin-4-one analogs as Mycobacterium tuberculosis DNA gyrase inhibitors

Future Journal of Pharmaceutical Sciences, 2021
Background Tuberculosis is evidently a major health threat among human populations worldwide. The current study presents the synthesis of new 3-((7-chloroquinolin-4-yl)amino)thiazolidin-4-one analogs (4a–o) as potential Mycobacterium tuberculosis DNA ...
Preeti S. Salve, Prajakta Parchure, Lisel Araujo, Rohini S. Kavalapure, Sunil S. Jalalpure, Dharmarajan Sriram, Vagolu Siva Krishna, Madhu Rekha Estharla, Shankar G. Alegaon   +8 more
doaj   +1 more source

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage [PDF]

, 2006
Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CLaction in the presence of topoisomerase IV from Streptococcus pneumoniae.
Fisher, LM, RICHTER, SARA, Giaretta, G, LEO, ELISABETTA, GIARETTA, GIULIA, Palumbo, M, Leo, E, FISHER L. M, Richter, SN, Gatto, B, GATTO, BARBARA, PALUMBO, MANLIO   +11 more
core   +1 more source

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis.
Laponogov, I, Pan, Xiao-Su, L Mark Fisher, Veselkov, DA, Sanderson, MR, Xiao-Su Pan, Sohi, MK, Mark R Sanderson, Fisher, L. Mark, Sanderson, Mark R., Laponogov, Ivan, Fisher, LM, Dennis A Veselkov, Pan, XS, Maninder K Sohi, Veselkov, Dennis A., Ivan Laponogov, Sohi, Maninder K.   +17 more
core   +1 more source

Conditional Silencing by CRISPRi Reveals the Role of DNA Gyrase in Formation of Drug-Tolerant Persister Population in Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology, 2019
Drug tolerance in mycobacterial pathogens is a global concern. Fluoroquinolone (FQ) treatment is widely used for induction of persisters in bacteria.
Eira Choudhary, Eira Choudhary, Rishabh Sharma, Yashwant Kumar, Nisheeth Agarwal   +4 more
doaj   +1 more source

Mathematical and experimental approaches to the dimer catastrophe theory [PDF]

, 2011
Multicopy plasmids rely on random distribution for stable inheritance by daughter cells at division. Threats to plasmid copy number increase the probability of plasmid loss, which can be detrimental to both plasmid and host. Plasmid dimers emerge through

core   +3 more sources

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus

Microbiology Spectrum, 2022
The aminobenzimidazole SPR719 targets DNA gyrase in Mycobacterium tuberculosis. The molecule acts as inhibitor of the enzyme’s ATPase located on the Gyrase B subunit of the tetrameric Gyrase A2B2 protein.
Wassihun Wedajo Aragaw, Nicole Cotroneo, Suzanne Stokes, Michael Pucci, Ian Critchley, Martin Gengenbacher, Thomas Dick   +6 more
doaj   +1 more source

DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.

PLoS Genetics, 2020
DNA supercoiling is essential for all living cells because it controls all processes involving DNA. In bacteria, global DNA supercoiling results from the opposing activities of topoisomerase I, which relaxes DNA, and DNA gyrase, which compacts DNA. These
Alexandre Duprey, Eduardo A Groisman
doaj   +1 more source

Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.

PLoS ONE, 2010
BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts, Christian Breuer, Melisa K Wall, Keiko Sugimoto-Shirasu, Anthony Maxwell   +4 more
doaj   +1 more source