Results 51 to 60 of about 1,477,235 (156)

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

DNA deformability in sequence-dependent capture of E. coli gyrase

Nature Communications
To understand how gyrase interacts with DNA and selects a site of action, we created an ad hoc shape-based recognition methodology to ascertain the DNA sequence from cryoEM density maps as a string of purines and pyrimidines, which matched to the DNA ...
Matthew L. Baker, Haley R. Johnson, Ryan A. Eckerty, Jonathan M. Fogg, Silvia L. Summers, Marlène Vayssières, Nils Marechal, Valérie Lamour, Wilma K. Olson, Lynn Zechiedrich   +9 more
doaj   +1 more source

New Potential Pharmacological Targets of Plant-Derived Hydroxyanthraquinones from Rubia spp.

Molecules, 2022
The increased use of polyphenols nowadays poses the need for identification of their new pharmacological targets. Recently, structure similarity-based virtual screening of DrugBank outlined pseudopurpurin, a hydroxyanthraquinone from Rubia cordifolia spp.
Petko Alov, Merilin Al Sharif, Hristo Najdenski, Tania Pencheva, Ivanka Tsakovska, Maya Margaritova Zaharieva, Ilza Pajeva   +6 more
doaj   +1 more source

Antimicrobial Sensitivity Profile and Resistance Gene Research in Escherichia coli Isolated From Water and Fish From Lagoa da Conceição, Florianópolis, SC, Brazil

Food Safety and Health, EarlyView.
This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento, Luan Amaral Alexandre, Cynthia Farias Manassi, Alice Cristina da Silva, Luísa Aimée Schmitt Lobe, Gustavo Rocha, Mateus Rocha Ribas, Victor Wolleck, Gabriele Caroline Gottschalk de Abreu, Alessandra Valéria Vortmann, Sheila Mello da Silveira, Rodrigo Barcellos Hoff, Jussara Kasuko Palmeiro, Silvani Verruck   +13 more
wiley   +1 more source

Molecular Characterization of the Gene Encoding the DNA Gyrase A Subunit of Streptococcus pneumoniae

, 1998
The gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae was cloned and sequenced. The gyrA gene codes for a protein of 822 amino acids homologous to the gyrase A subunit of eubacteria.
Balas, Delia, Campa, Adela G. de la, Fernández Moreira, Esteban   +2 more
core   +1 more source

Extraction of Antimicrobial Peptides From Fava Bean Protein Hydrolyzate by Phosphorylated Biochar

Food Safety and Health, EarlyView.
Antimicrobial peptides were extracted by functional biochar in one step. The enriched peptides demonstrated significantly enhanced antibacterial activity. ABSTRACT The extraction of antimicrobial peptides (AMPs) from plant proteins remains challenging due to their low abundance, structural diversity, and the need for mild, efficient, and selective ...
Xiang‐Yu Huang, Hao‐Ran Liu, Rong Guo, Li Ding, Li Wen, Xu‐Feng Wang, Zhou Xu, Yun‐Hui Cheng, Mao‐Long Chen   +8 more
wiley   +1 more source

The interaction of quinolone antibacterials with DNA gyrase.

, 1993
Quinolone drags are a clinically significant family of antibacterial compounds that are known to affect the activity of DNA gyrase, an essential bacterial enzyme involved in controlling the topological state of DNA, Gyrase holoenzyme, a complex of two A ...
Christopher John Rowan. Willmott (7633793)
core   +5 more sources

Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase

Molecules, 2017
Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conformation after ...
Dawei Li, Qiang Wang, Yun Liu, Kun Liu, Qiang Zhuge, Bei Lv   +5 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source