Results 51 to 60 of about 19,626 (172)

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

One Health Insights From Pteropus medius: Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Environmental and anthropogenic drivers of antibiotic resistance dissemination. The cycle reinforces how anthropogenic inputs, such as sewage, animal dung, hospital effluent, and agricultural runoff bring resistant bacteria and antibiotic residues into soil and water.
Punam Chowdhury, Shah Md Tanvir Khan, Sajal Roy, Md. Shohel Al Faruk   +3 more
wiley   +1 more source

Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Background Helicobacter spp. are gastric or enterohepatic bacteria that can be commensal, opportunistic, or pathogenic. Few studies have evaluated Helicobacter spp. in baboons. Methods Twenty‐seven captive baboons were surveyed for Helicobacter spp. by fecal PCR, and a subset evaluated by culture.
Isabel A. Jimenez, Courtney Lunger, Marcus J. Crim, Shannon L. Primm, Anthony Mannion, Nathan P. Crilly, Lydia M. Hopper, Lindsey G. Thurman, Linnette L. Vasquez, Cory Brayton, Yan Feng, James G. Fox, Zeli Shen, Jessica M. Izzi   +13 more
wiley   +1 more source

Prophage Gifsy-1 Induction in Salmonella enterica Serovar Typhimurium Reduces Persister Cell Formation after Ciprofloxacin Exposure

Microbiology Spectrum, 2023
Persister cells are drug-tolerant bacteria capable of surviving antibiotic treatment despite the absence of heritable resistance mechanisms. It is generally thought that persister cells survive antibiotic exposure through the implementation of stress ...
Sebastian Braetz, Peter Schwerk, Nara Figueroa-Bossi, Karsten Tedin, Marcus Fulde   +4 more
doaj   +1 more source

Immunomodulatory Potential of Quinoline Q3, a Selective Inhibitor of the Canonical NF‐κB Pathway in Macrophages

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
The quinolone Q3 specifically enhances the DNA binding of the p50/p50 NF‐κB dimers, while inhibiting the activity of the p65 transcriptional activator, resulting in inhibition of the NF‐κB canonical pathway in lipopolysaccharide (LPS)‐stimulated macrophages.
Konstantinos Michail, Panagiotis Ntavaroukas, Vasiliki Petriki, Evangelos Tsioupros, Stella Manta, Barry J. Campbell, Stamatia Papoutsopoulou   +6 more
wiley   +1 more source

BioEISense: A Microfluidic Platform for Real‐Time Monitoring of Staphylococcus aureus Biofilm Formation and the Efficacy of Antibiofilm Agents

Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.
BioEISense is a microfluidic device with integrated impedance sensors, for real‐time, label‐free monitoring of S. aureus biofilms. In this study, the biofilm culture conditions were optimized to support sensitive and reproducible detection of biofilm formation and eradication under dynamic flow‐through conditions. The system was also validated for both
Jéssica Amorim, Laura Vesalainen, Loïc Dreano, Markus Haapala, Cristina D. Cruz, Päivi Tammela, Tiina M. Sikanen   +6 more
wiley   +1 more source

Antigonococcal Activity and Cytotoxicity Screening of Three Ziziphus Species Indigenous to South Africa

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Ziziphus species in South Africa are widely used to treat gonorrhea; however, to this day, there has been no scientific validation of their ethnomedicinal use. This study tentatively identified phytol, betulin, and hexadecanoic acid to be linked to the observed antigonococcal activity.
Mcebisi J. Mabuza, Marcel Kaiser, Thilivhali E. Tshikalange, Abdullahi A. Yusuf, Mahwahwatse J. Bapela   +4 more
wiley   +1 more source

DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae

Scientific Reports, 2019
Leprosy, an important infectious disease in humans caused by Mycobacterium leprae (Mle), remains endemic in many countries. Notably, the pathogen cannot be cultured in vitro, except in mouse footpads in vivo.
Hyun Kim, Yasuo Fukutomi, Chie Nakajima, Youn Uck Kim, Shigetarou Mori, Keigo Shibayama, Noboru Nakata, Yasuhiko Suzuki   +7 more
doaj   +1 more source

The influence of DNA gyrase on the transcription of linear DNA in vitro [PDF]

FEBS Letters, 1982
DNA gyrase could negatively supercoil DNA in an ATP-driven reaction. Numerous data obtained both in vivo and in vitro show the depression of such vital processes as replication and transcription and of integrative recombination by the inhibitors of DNA gyrase [ 11. These data prove that for proper functioning the DNA should be supercoiled.
Shmerling, Zh.G., Gragerov, A.I.
openaire   +2 more sources

Comprehensive Phytochemical Profiling and Multi‐Target Biological Evaluation of Hibiscus sabdariffa L. Calyx Extracts From Libya: A Promising Functional Food Candidate With Antibacterial, Antioxidant, Anti‐Inflammatory, and Cytotoxic Properties: Validation Through In Silico Approaches

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study presents a comprehensive evaluation of Hibiscus sabdariffa L. calyx extracts from Libya, integrating phytochemical profiling, multi‐target biological activities, and in silico validation. Aqueous and ethanolic extracts were prepared and assessed for antibacterial activity against multidrug‐resistant clinical isolates (MIC: 6.25–25 mg/mL; MBC/
Ahmed Saeed Kabbashi, Zuhir S. Mussa Akrim, Mohammed B. Suliman, Sanadelaslam S. A. El‐Hddad, Ahmed Ali Mustafa, Maryam Mohammed Ibrahim, Esraa Radwan Ibrahim, Mona Rafea Mosa, Rama Burhan Hasan   +8 more
wiley   +1 more source