Results 41 to 50 of about 19,626 (172)

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Antimicrobial Sensitivity Profile and Resistance Gene Research in Escherichia coli Isolated From Water and Fish From Lagoa da Conceição, Florianópolis, SC, Brazil

Food Safety and Health, EarlyView.
This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento, Luan Amaral Alexandre, Cynthia Farias Manassi, Alice Cristina da Silva, Luísa Aimée Schmitt Lobe, Gustavo Rocha, Mateus Rocha Ribas, Victor Wolleck, Gabriele Caroline Gottschalk de Abreu, Alessandra Valéria Vortmann, Sheila Mello da Silveira, Rodrigo Barcellos Hoff, Jussara Kasuko Palmeiro, Silvani Verruck   +13 more
wiley   +1 more source

Extraction of Antimicrobial Peptides From Fava Bean Protein Hydrolyzate by Phosphorylated Biochar

Food Safety and Health, EarlyView.
Antimicrobial peptides were extracted by functional biochar in one step. The enriched peptides demonstrated significantly enhanced antibacterial activity. ABSTRACT The extraction of antimicrobial peptides (AMPs) from plant proteins remains challenging due to their low abundance, structural diversity, and the need for mild, efficient, and selective ...
Xiang‐Yu Huang, Hao‐Ran Liu, Rong Guo, Li Ding, Li Wen, Xu‐Feng Wang, Zhou Xu, Yun‐Hui Cheng, Mao‐Long Chen   +8 more
wiley   +1 more source

New Potential Pharmacological Targets of Plant-Derived Hydroxyanthraquinones from Rubia spp.

Molecules, 2022
The increased use of polyphenols nowadays poses the need for identification of their new pharmacological targets. Recently, structure similarity-based virtual screening of DrugBank outlined pseudopurpurin, a hydroxyanthraquinone from Rubia cordifolia spp.
Petko Alov, Merilin Al Sharif, Hristo Najdenski, Tania Pencheva, Ivanka Tsakovska, Maya Margaritova Zaharieva, Ilza Pajeva   +6 more
doaj   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

European Journal of Medicinal Chemistry Reports
DNA gyrase is a member of the DNA topoisomerase protein family that catalyzes the conversion of different topological forms of DNA into one another. It is the sole enzyme that causes DNA to negatively supercoil. The enzyme is tetrameric with two GyrA (“A'
K. Rajakumari, K. Aravind, M. Balamugundhan, Manjunathan Jagadeesan, Ambiga Somasundaram, Parthiban Brindha Devi, Pasiyappazham Ramasamy   +6 more
doaj   +1 more source

Outbreaks of Granulomatous Disease Associated With Vibrio harveyi Infection in Grouper (Epinephelus fuscoguttatus × E. lanceolatus) Aquaculture in Taiwan

Journal of Fish Diseases, EarlyView.
ABSTRACT Between 2015 and 2024, outbreaks of muscular and visceral granulomatous disease, resulting in moderate‐to‐severe mortality in farmed groupers, occurred in southern Taiwan. Initially, affected groupers were screened for granuloma‐associated pathogens, including Mycobacterium spp., Nocardia spp., Photobacterium damselae and Edwardsiella spp ...
Shang‐Ting Wu, Chia‐Yu Hsieh
wiley   +1 more source

DNA deformability in sequence-dependent capture of E. coli gyrase

Nature Communications
To understand how gyrase interacts with DNA and selects a site of action, we created an ad hoc shape-based recognition methodology to ascertain the DNA sequence from cryoEM density maps as a string of purines and pyrimidines, which matched to the DNA ...
Matthew L. Baker, Haley R. Johnson, Ryan A. Eckerty, Jonathan M. Fogg, Silvia L. Summers, Marlène Vayssières, Nils Marechal, Valérie Lamour, Wilma K. Olson, Lynn Zechiedrich   +9 more
doaj   +1 more source

Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase

Molecules, 2017
Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conformation after ...
Dawei Li, Qiang Wang, Yun Liu, Kun Liu, Qiang Zhuge, Bei Lv   +5 more
doaj   +1 more source

Solution structures of DNA-bound gyrase [PDF]

Nucleic Acids Research, 2010
The DNA gyrase negative supercoiling mechanism involves the assembly of a large gyrase/DNA complex and conformational rearrangements coupled to ATP hydrolysis. To establish the complex arrangement that directs the reaction towards negative supercoiling, bacterial gyrase complexes bound to 137- or 217-bp DNA fragments representing the starting ...
Nicole M. Baker, Steven Weigand, Sarah Maar-Mathias, Alfonso Mondragón   +3 more
openaire   +2 more sources