Results 41 to 50 of about 1,477,235 (156)
Discovery of Novel Bacterial DNA Gyrase Inhibitors [PDF]
, 2023 Bacterial DNA gyrase is a type IIA DNA topoisomerase. Due to its essential role in DNA replication and transcription, this enzyme is a validated target for discovering and developing new antibiotics.
Alfonso Maqueira, Eddy E.
core
International Journal of Medical Microbiology, 2020 Allicin (diallylthiosulfinate) is a potent antimicrobial substance, produced by garlic tissues upon wounding as a defence against pathogens and pests.
Jana Reiter +4 more
doaj +1 more source
In silico analysis of ciprofloxacin analogs as inhibitors of DNA gyrase of Staphylococcus aureus
Informatics in Medicine Unlocked, 2021 In this in silico study, thirty-five ciprofloxacin analogs were docked to the active site of DNA gyrase, the prime target of ciprofloxacin type antibiotics. Prior to docking all the structures were optimized using MM2 force field parameters.
Md. Rakhibul Hasan +7 more
doaj +1 more source
Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone
Advanced Science, EarlyView.A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad +12 more
wiley +1 more source
, 2009 The genes encoding the subunits of DNA topoisomerase IV (parC and parE) and DNA gyrase (gyrA and gyrB) of Streptococcus pneumoniae were cloned and overproduced in Escherichia coli by using the T7promoter-T7 RNA polymerase system.
Balas, Delia +3 more
core +1 more source
Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
Nature Communications, 2019 Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-
Arnaud Vanden Broeck +3 more
doaj +1 more source
Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
wiley +1 more source
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
Albicidin, a potent DNA gyrase inhibitor with clinical potential
, 2019 The emergence of multiple antibiotic-resistant bacteria is a serious global problem which requires the development of new effective antimicrobial therapeutics.
Saeed Mujahid Hashimi +1 more
core +1 more source
Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development
European Journal of Medicinal Chemistry ReportsDNA gyrase is a member of the DNA topoisomerase protein family that catalyzes the conversion of different topological forms of DNA into one another. It is the sole enzyme that causes DNA to negatively supercoil. The enzyme is tetrameric with two GyrA (“A'
K. Rajakumari +6 more
doaj +1 more source