Results 1 to 10 of about 21,111 (116)

DNA deformability in sequence-dependent capture of E. coli gyrase [PDF]

Nature Communications
To understand how gyrase interacts with DNA and selects a site of action, we created an ad hoc shape-based recognition methodology to ascertain the DNA sequence from cryoEM density maps as a string of purines and pyrimidines, which matched to the DNA ...
Matthew L. Baker, Haley R. Johnson, Ryan A. Eckerty, Jonathan M. Fogg, Silvia L. Summers, Marlène Vayssières, Nils Marechal, Valérie Lamour, Wilma K. Olson, Lynn Zechiedrich   +9 more
doaj   +2 more sources

Design, synthesis, and antibacterial assessment of a new series of ciprofloxacin-based compounds as possible dual DNA gyrase/topoisomerase IV inhibitors [PDF]

Scientific Reports
Simultaneous inhibition of DNA gyrase and topoisomerase IV (Topo IV) is a primary pharmacological strategy to enhance antibacterial efficacy and markedly reduce the emergence of antibiotic resistance.
Lamya H. Al-Wahaibi, Hayat Ali Alzahrani, Stefan Bräse, Bahaa G. M. Youssif, Mohamed Hisham   +4 more
doaj   +2 more sources

Structural and Computational Analysis of Pseudomonas aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to Ciprofloxacin Resistance [PDF]

Biomolecules
Pseudomonas aeruginosa is considered a priority pathogen by the World Health Organization due to its resistance to antibiotics. Isolates resistant to ciprofloxacin (CPFX), a bactericide commonly used against P.
Lalith Perera, Libertad García-Villada, Andrea M. Kaminski, Natalya Degtyareva, Lars C. Pedersen, Paul W. Doetsch   +5 more
doaj   +2 more sources

Investigating Escherichia coli Colicin E9 immunity protein interactions with DNA gyrase of Pseudomonas aeruginosa: advanced computational approach for developing novel antimicrobial strategies [PDF]

Scientific Reports
Protein-protein interactions (PPIs) are essential to numerous cellular processes, making a thorough investigation of these interactions crucial for a deeper understanding of molecular mechanisms.
Rihaf Alfaraj, Fai Alkathiri, Rupesh Chikhale   +2 more
doaj   +2 more sources

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors

Pharmaceuticals, 2021
A novel series of ciprofloxacin hybrids comprising various heterocycle derivatives has been synthesized and structurally elucidated using 1H NMR, 13C NMR, and elementary analyses.
Lamya H. Al-Wahaibi, Amer A. Amer, Adel A. Marzouk, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Antar A. Abdelhamid   +5 more
doaj   +1 more source

Towards Conformation-Sensitive Inhibition of Gyrase: Implications of Mechanistic Insight for the Identification and Improvement of Inhibitors

Molecules, 2021
Gyrase is a bacterial type IIA topoisomerase that catalyzes negative supercoiling of DNA. The enzyme is essential in bacteria and is a validated drug target in the treatment of bacterial infections.
Dagmar Klostermeier
doaj   +1 more source

Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa

mSystems, 2021
The design of novel antibiotics relies on a profound understanding of their mechanism of action. While it has been shown that cellular effects of antibiotics cluster according to their molecular targets, we investigated whether compounds binding to ...
Raimo Franke, Heike Overwin, Susanne Häussler, Mark Brönstrup   +3 more
doaj   +1 more source

Bacterial Argonaute Proteins Aid Cell Division in the Presence of Topoisomerase Inhibitors in Escherichia coli

Microbiology Spectrum, 2023
Prokaryotic Argonaute (pAgo) proteins are guide-dependent nucleases that function in host defense against invaders. Recently, it was shown that TtAgo from Thermus thermophilus also participates in the completion of DNA replication by decatenating ...
Anna Olina, Aleksei Agapov, Denis Yudin, Dmitry Sutormin, Alina Galivondzhyan, Anton Kuzmenko, Konstantin Severinov, Alexei A. Aravin, Andrey Kulbachinskiy   +8 more
doaj   +1 more source

Synthesis, In Silico and In Vitro Antimicrobial Evaluation of Cyanoketene S,N-Acetals and their Pyrazoles Against Staphylococcus aureus DNA Gyrase Enzyme [PDF]

Journal of Advanced Pharmacy Research, 2021
Objectives: The continuous reporting of bacterial resistance to antibiotics is an ongoing challenge that can be life-threatening. Actions to develop new chemicals to overcome the bacterial resistance has gained a significant importance. Methods: A series
Ashraf Hassan, Khaled Abouzid, Shima Ali, Sherif Hammad, Ahmed H.I. Faraag, Taghrid El-Mahdy, Ahmed Askar, Hossam Elgiushy   +7 more
doaj   +1 more source

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens

Antibiotics, 2022
DNA gyrase and topoisomerase IV are proven to be validated targets in the design of novel antibacterial drugs. In this study, we report the antibacterial evaluation and molecular docking studies of previously synthesized two series of cyclic ...
Neveen M. Saleh, Yasmine S. Moemen, Sara H. Mohamed, Ghady Fathy, Abdullah A. S. Ahmed, Ahmed A. Al-Ghamdi, Sami Ullah, Ibrahim El-Tantawy El Sayed   +7 more
doaj   +1 more source