Results 21 to 30 of about 25,820 (160)

CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

eLife, 2018
Gyrase is a unique type IIA topoisomerase that uses ATP hydrolysis to maintain the negatively supercoiled state of bacterial DNA. In order to perform its function, gyrase undergoes a sequence of conformational changes that consist of concerted gate ...
Katarzyna M Soczek, Tim Grant, Peter B Rosenthal, Alfonso Mondragón   +3 more
doaj   +1 more source

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases [PDF]

, 2007
Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase ...
GIARETTA G, COMUZZI V, Palumbo, M, Leo, E, Mitchenall, LA, Richter, SN, Maxwell, A, Fisher, LM, RICHTER, SARA, Giaretta, G, LEO E, MAXWELL A, Comuzzi, V, FISHER LM, MITCHENALL LA, PALUMBO, MANLIO   +15 more
core   +1 more source

Pyrene-linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights. [PDF]

Smart Mol
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Kasundra DV, Patel PN.
europepmc   +2 more sources

A RADAR-Based Assay to Isolate Covalent DNA Complexes in Bacteria

Antibiotics, 2019
Quinolone antibacterials target the type II topoisomerases gyrase and topoisomerase IV and kill bacterial cells by converting these essential enzymes into cellular poisons. Although much is known regarding the interactions between these drugs and enzymes
Katie J. Aldred, Adeline Payne, Olivia Voegerl   +2 more
doaj   +1 more source

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis.
Laponogov, I, Pan, Xiao-Su, L Mark Fisher, Veselkov, DA, Sanderson, MR, Xiao-Su Pan, Sohi, MK, Mark R Sanderson, Fisher, L. Mark, Sanderson, Mark R., Laponogov, Ivan, Fisher, LM, Dennis A Veselkov, Pan, XS, Maninder K Sohi, Veselkov, Dennis A., Ivan Laponogov, Sohi, Maninder K.   +17 more
core   +1 more source

Conditional Silencing by CRISPRi Reveals the Role of DNA Gyrase in Formation of Drug-Tolerant Persister Population in Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology, 2019
Drug tolerance in mycobacterial pathogens is a global concern. Fluoroquinolone (FQ) treatment is widely used for induction of persisters in bacteria.
Eira Choudhary, Eira Choudhary, Rishabh Sharma, Yashwant Kumar, Nisheeth Agarwal   +4 more
doaj   +1 more source

Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities

Antibiotics, 2017
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death.
Temilolu Idowu, Frank Schweizer
doaj   +1 more source

Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola [PDF]

, 2009
Submarine hydrothermal vents are model systems for the Archaean Earth environment, and some sites maintain conditions that may have favored the formation and evolution of cellular life.
Robinson, Jeffrey M, Campbell, Barbara J, Hoda M Khouri, S. Craig Cary, Hanson, Thomas E., Lee Charles K., Jonathan A. Eisen, Wu, Dongying, Eisen, Jonathan A., Barbara J Campbell, Jeffrey M Robinson, Cary, S Craig, Robinson, Jeffrey M., Charles K. Lee, Stein, Lisa Y., Lisa Y Stein, Stein, Lisa Y, Julie L Smith, Thomas E Hanson, Klotz, Martin G., Cary S. Craig, Eisen, Jonathan A, Khouri Hoda M., Khouri, Hoda M, Hanson, Thomas E, Hanson Thomas E., Eisen Jonathan A., Thomas E. Hanson, Dongying Wu, S Craig Cary, Jonathan A Eisen, Lee, Charles K, Smith, Julie L., Klotz Martin G., Cary, S. Craig, Wu Dongying, Charles K Lee, Smith Julie L., Martin G. Klotz, Campbell, Barbara J., Klotz, Martin G, Campbell Barbara J., Barbara J. Campbell, Julie L. Smith, Lee, Charles Kai-Wu, Khouri, Hoda M., Smith, Julie L, Lisa Y. Stein, Jeffrey M. Robinson, Hoda M. Khouri, Martin G Klotz, Stein Lisa Y., Robinson Jeffrey M.   +52 more
core   +2 more sources

Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection

Frontiers in Microbiology, 2019
Methicillin-resistant Staphylococcus aureus (MRSA) is the primary microbe responsible for skin infections that are particularly difficult to eradicate.
Shih-Chun Yang, Kai-Wei Tang, Chih-Hung Lin, Ahmed Alalaiwe, Chih-Hua Tseng, Chih-Hua Tseng, Chih-Hua Tseng, Chih-Hua Tseng, Jia-You Fang, Jia-You Fang, Jia-You Fang, Jia-You Fang   +11 more
doaj   +1 more source

Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives. [PDF]

PLoS ONE, 2013
A total of 19 novel (3a-3s) N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide analogs were designed, synthesized, and evaluated for biological activities as potential DNA gyrase inhibitors. The results showed that compound 3k can strongly inhibit
Juan Sun, Peng-Cheng Lv, Yong Yin, Rong-Ju Yuan, Jian Ma, Hai-Liang Zhu   +5 more
doaj   +1 more source