Results 31 to 40 of about 25,820 (160)
Mathematical and experimental approaches to the dimer catastrophe theory [PDF]
, 2011 Multicopy plasmids rely on random distribution for stable inheritance by daughter cells at division. Threats to plasmid copy number increase the probability of plasmid loss, which can be detrimental to both plasmid and host. Plasmid dimers emerge through
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The Current Case of Quinolones: Synthetic Approaches and Antibacterial Activity
Molecules, 2016 Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available for clinical consumption in 1962 and was used mainly for urinary tract ...
Abdul Naeem +4 more
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Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India. [PDF]
PLoS ONE, 2015 Enteric fever is a major cause of morbidity in several parts of the Indian subcontinent. The treatment for typhoid fever majorly includes the fluoroquinolone group of antibiotics.
Manoj Kumar +6 more
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The bacteriophage LUZ24 “Igy” peptide inhibits the Pseudomonas DNA gyrase
Cell Reports, 2021 Summary: The bacterial DNA gyrase complex (GyrA/GyrB) plays a crucial role during DNA replication and serves as a target for multiple antibiotics, including the fluoroquinolones.
Jeroen De Smet +9 more
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Discovery of Novel Bacterial DNA Gyrase Inhibitors [PDF]
, 2023 Bacterial DNA gyrase is a type IIA DNA topoisomerase. Due to its essential role in DNA replication and transcription, this enzyme is a validated target for discovering and developing new antibiotics.
Alfonso Maqueira, Eddy E.
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Scientific Reports, 2023 Flavonoids are plant-produced secondary metabolites that are found ubiquitously. We have previously reported that apigenin, a class of flavonoid, has unique antimicrobial activity against Staphylococcus aureus (S.
Yuh Morimoto +6 more
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Microbiology Spectrum, 2022 The aminobenzimidazole SPR719 targets DNA gyrase in Mycobacterium tuberculosis. The molecule acts as inhibitor of the enzyme’s ATPase located on the Gyrase B subunit of the tetrameric Gyrase A2B2 protein.
Wassihun Wedajo Aragaw +6 more
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The interaction of quinolone antibacterials with DNA gyrase.
, 1993 Quinolone drags are a clinically significant family of antibacterial compounds that are known to affect the activity of DNA gyrase, an essential bacterial enzyme involved in controlling the topological state of DNA, Gyrase holoenzyme, a complex of two A ...
Christopher John Rowan. Willmott (7633793)
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The unusual mode of action of the polyketide glycoside antibiotic cervimycin C
mSphereCervimycins A–D are bis-glycosylated polyketide antibiotics produced by Streptomyces tendae HKI 0179 with bactericidal activity against Gram-positive bacteria.
Alina Hoffmann +9 more
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Complexation of norfloxacin with DNA in the presence of caffeine [PDF]
, 2006 1H NMR spectroscopy (500 MHz) has been used to quantify the complexation of the antibacterial antibiotic Norfloxacin (NOR) with DNA in the presence of Caffeine (CAF). Separate studies have been made for the self-association of NOR, its hetero-association
Davies, David B. +2 more
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