Results 71 to 80 of about 19,626 (172)

Isomer Engineering of NIR‐II Aggregation‐Induced Emission for the Theranostics of MRSA‐Induced Abscess

Aggregate, Volume 7, Issue 6, June 2026.
This work presents a positional isomer engineering strategy to create a microenvironment‐tolerant NIR‐II AIEgen. The para‐isomer exhibits optimized excited‐state dynamics, enabling potent Type‐I photodynamic activity under hypoxia along with photothermal conversion.
Wentian Zhang, Haifei Wen, Ximing Chen, Tianxing Liu, Yuanyuan Li, Zhiliang Yu, Linjie Tan, Shichuang Xu, Parvej Alam, Zheng Zhao, Ying Li, Junfeng Dong, Ben Zhong Tang   +12 more
wiley   +1 more source

Computational Analysis of DNA Gyrase Action [PDF]

Biophysical Journal, 2004
DNA gyrase introduces negative supercoiling into circular DNA by catalyzing the passage of one DNA segment through another. The efficiency of the reaction is many times higher than that of other topological transformations. We analyze, by a computer simulation, the reaction selectivity for a model of DNA gyrase action that assumes existence of a free ...
openaire   +2 more sources

Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2018
Context: Bacterial resistance to antibiotics is the inevitable consequence of the use of antimicrobial agents. Thus, quinolones are an important class of antibacterials; these agents generally consist of a 1-subtituted-1,4-dihydro-4-oxopyridine-3 ...
Cristian Davila, Lorena Llach, Guillermo Salgado-Moran, Rodrigo Ramirez-Tagle   +3 more
doaj  

In-silico design of some tetrazoloquinoline analogs as potent inhibitors of DNA gyrase of Salmonella typhi: QSAR modeling, molecular docking, MD simulation, and ADMET profiling

In Silico Research in Biomedicine
The rising incidences of multi-drug resistance in Salmonella typhi have made the WHO to enlist the bacteria among the highest priority pathogens group that requires urgent attention.
Philip John Ameji, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba, Muhammad Tukur Ibrahim   +4 more
doaj   +1 more source

The cleavage of DNA at phoshorothioate internucleotidic linkages by DNA gyrase

Nucleic Acids Research, 1992
We have constructed a plasmid which contains 22 copies of a 147 bp DNA fragment which contains the major DNA gyrase cleavage site from plasmid pBR322 (located at base-pair 990). We have found that this fragment is efficiently bound and cleaved by gyrase.
Dobbs, S. T., Cullis, P. M., Maxwell, A.
openaire   +4 more sources

Molecular Docking analysis of the antibacterial effect of pomegranate (Punica granatum) fruit molasses bioactive compounds [PDF]

Benha Veterinary Medical Journal
Pomegranate molasses is a one of functional element that has generated extensive scientific attention in the search for effective bioactive natural compounds.
Hanaa Bekeir, Ahmed Hamad, Nesreen Eleiwa, reham Amin   +3 more
doaj   +1 more source

Antimicrobial Activity of 2-(Piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione against Staphylococcus Strains

Molecules
There is an urgent need to discover and develop novel antibacterial agents. Accordingly, we synthesised 2-(piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione (PNT), which exhibits antimicrobial activity.
Tamami Haraguchi, Saki Hayashi, Seira Nakasaka, Yoshiro Hatanaka, Toshihiro Nagao, Shigemitsu Tanaka, Miki Yoshii, Fumiko Hara, Masayori Hagimori, Miyako Yoshida   +9 more
doaj   +1 more source

Identification of novel bacterial DNA gyrase inhibitors: An in silico study

Research in Pharmaceutical Sciences, 2016
Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly emerging resistance to gyrase-targeted drugs such as widely utilized fluoroquinolones reveals the necessity to develop novel ...
Hamzeh Rahimi, Ali Najafi, Habib Eslami, Babak Negahdari, Mehrdad Moosazadeh Moghaddam   +4 more
doaj  

Broken beyond repair: TA system ParE toxins mediate effective gyrase inhibition without driving resistance

Journal of Bacteriology
DNA gyrase is an essential bacterial-specific type IIA topoisomerase that corrects DNA overwinding during transcription and replication. Compounds capable of stabilizing gyrase-mediated double-strand DNA breaks are valuable antibacterials; however, these
Chih-Han Tu, Shengfeng Ruan, Michelle Holt, Christina R. Bourne   +3 more
doaj   +1 more source

DNA Gyrase and DNA Supercoiling

Cold Spring Harbor Symposia on Quantitative Biology, 1979
M, Gellert, K, Mizuuchi, M H, O'Dea, H, Ohmori, J, Tomizawa   +4 more
openaire   +2 more sources