Results 81 to 90 of about 1,477,235 (156)

Metagenomic Characterisation of Antibiotic Resistance in Anaerobic Digesters and Their Implications for Environmental Health

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Anaerobic digester metagenomes revealed diverse resistance‐associated annotations and antibiotic target loci, highlighting their potential role in environmental AMR surveillance. The findings emphasise the need for cautious interpretation of resistome profiles and further host‐resolved analyses to determine the mobility and clinical relevance of ...
Olasunbo Aina Olasupo, Oluwaseyi Paul Olaniyan, Sunday Babatunde Akinde, Ademola Ayodele Adesoye, Fatimah Adenike Ajadi, Omokaro Obire, Elijah Kolawole Oladipo, Waidi Folorunso Sule, Olamilekan Emmanuel Oyinloye, Adedolapo Aishat Salami, Emmanuel Sunday Fajoyegbe, Adejoke Janet Ajani, Olabisi Ojo   +12 more
wiley   +1 more source

Redefining Fluoroquinolone Antibiotics: Design and Synthesis of Degradable Fluoroquinolones to Reduce Environmental Persistence

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
Redesign and development of an efficient, robust synthesis platform for environmentally improved fluoroquinolones. A significant challenge associated with antibiotics, and active pharmaceutical ingredients in general, is their intentional design for high stability, which promotes environmental persistence and contributes to the development of ...
Nathan Raeymackers, Emile De Mol, Martin Yenokyan, Morten Suk, Klaus Kümmerer, Thomas S. A. Heugebaert, Christian V. Stevens   +6 more
wiley   +1 more source

Rapid, DNA-induced subunit exchange by DNA gyrase [PDF]

DNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the active complex.
Baskerville, Victoria, Maxwell, Anthony, Bush, Natassja, Saman, Dominik, Germe, Thomas, Benesch, Justin   +5 more
core   +1 more source

DNA gyrase : mechanism of supercoiling and interaction with quinolones

, 1998
DNA gyrase is unique among topoisomerases in its ability to introduce negative supercoils into closed-circular DNA. Deletion of the C-terminal DNA-binding domain of the A subunit of gyrase gives rise to an enzyme that behaves like a conventional type II
Sotirios C. Kampranis (564823)
core   +4 more sources

Antimicrobial Activity of 2-(Piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione against Staphylococcus Strains

Molecules
There is an urgent need to discover and develop novel antibacterial agents. Accordingly, we synthesised 2-(piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione (PNT), which exhibits antimicrobial activity.
Tamami Haraguchi, Saki Hayashi, Seira Nakasaka, Yoshiro Hatanaka, Toshihiro Nagao, Shigemitsu Tanaka, Miki Yoshii, Fumiko Hara, Masayori Hagimori, Miyako Yoshida   +9 more
doaj   +1 more source

Broken beyond repair: TA system ParE toxins mediate effective gyrase inhibition without driving resistance

Journal of Bacteriology
DNA gyrase is an essential bacterial-specific type IIA topoisomerase that corrects DNA overwinding during transcription and replication. Compounds capable of stabilizing gyrase-mediated double-strand DNA breaks are valuable antibacterials; however, these
Chih-Han Tu, Shengfeng Ruan, Michelle Holt, Christina R. Bourne   +3 more
doaj   +1 more source

Molecular Docking analysis of the antibacterial effect of pomegranate (Punica granatum) fruit molasses bioactive compounds [PDF]

Benha Veterinary Medical Journal
Pomegranate molasses is a one of functional element that has generated extensive scientific attention in the search for effective bioactive natural compounds.
Hanaa Bekeir, Ahmed Hamad, Nesreen Eleiwa, reham Amin   +3 more
doaj   +1 more source

Coordinated topoisomerase function shapes the fluoroquinolone response of Chlamydia trachomatis

Microbiology Spectrum
DNA supercoiling is essential for the developmental cycle of Chlamydia trachomatis, yet its role in shaping antibiotic responses remains poorly understood. We investigated how the fluoroquinolone moxifloxacin (Mox), a potent DNA gyrase inhibitor, affects
Andrew Terrebonne, Caitlynn Diggs, Scot P. Ouellette, Leiqiong Gao, Yuk-Ching Tse-Dinh, Li Shen   +5 more
doaj   +1 more source

Identification of novel bacterial DNA gyrase inhibitors: An in silico study

Research in Pharmaceutical Sciences, 2016
Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly emerging resistance to gyrase-targeted drugs such as widely utilized fluoroquinolones reveals the necessity to develop novel ...
Hamzeh Rahimi, Ali Najafi, Habib Eslami, Babak Negahdari, Mehrdad Moosazadeh Moghaddam   +4 more
doaj  

In-Silico Study of Urea Derivatives as a Potential DNA-Gyrase Inhibitors in Salmonella typhi

Journal of Microbiological Sciences
Salmonella Typhi is the infectious agent that causes typhoid fever. Among this disease's clinical symptoms are elevated body fever, headache, indigestion, body aches, fatigue, and cough. Salmonella Typhi is a pathogenic, rod-shaped, flagellated, and Gram-
Adnan Shahzad, Naseer Ullah, Fazal Dayan, Husna Iqbal, Asad Ullah Khan, Sunbal Khan, Naila, Rafi Ullah, Zahoor Ahamd, Muhammad Talha, Ihsan Ullah, Muhammad Omer, Imad Ud Din, Muhammad Ashfaq, Saqib Ahmad, Izhar Ahmad   +15 more
doaj   +1 more source