Results 91 to 100 of about 1,477,235 (156)

In silico analysis of luteolin derivatives as antibacterial agents targeting DNA gyrase and CTX-M-15 extended-spectrum β-lactamase of Escherichia coli

Journal of Advanced Pharmaceutical Technology & Research
Luteolin exhibited antibacterial activity against Escherichia coli and its chemical structure similar to that of ciprofloxacin (CPF) which works by inhibiting DNA gyrase.
Nuzul Wahyuning Diyah, Dwi Ayu Indriani, Rachma Dessidianti, Siswandono Siswandono   +3 more
doaj   +1 more source

The molecular basis of quinolone drug action on DNA gyrase.

, 1996
Quinolones are a clinically-useful class of antibacterial agents known to target DNA gyrase, a bacterial type II topoisomerase. Gyrase is unique among topoisomerases in its ability to introduce negative supercoils into DNA using the energy derived from ...
Susan Elizabeth. Critchlow (7702562)
core   +3 more sources

DAUN Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz SEBAGAI ANTI-Escherichia coli: STUDI IN SILICO DAN IN VITRO

JIIS: Jurnal Ilmiah Ibnu Sina
Penelitian ini dilakukan untuk mengetahui potensi kandungan fitokimia dalam menghasilkan aktivitas antibakteri dari ekstrak etanol 70% daun Balik Angin (Alphitonia incana (Roxb.) Teijsm. & Binn.
Hafiz Ramadhan, Dyera Forestryana, Wahyudin Bin Jamaludin, Ahmad Nur Hadi, Raudatunnisa   +4 more
doaj   +1 more source

DNA gyrase stimulates transcription.

, 1980
The nuclear DNA of HeLa cells can now be isolated unbroken and supercoiled. Using DNA gyrase and the untwisting enzyme, we have prepared an allomorphic series of templates derived from this nuclear DNA, and also from the circular DNA of the bacterial ...
Akrigg, A, Cook, Peter, Cook, PR
core  

Computational Evaluation of Antibacterial Activity of Acalypha indica L. Phytochemicals Against Staphylococcus aureus DNA Gyrase

Biology, Medicine & Natural Product Chemistry
This study investigated the antibacterial potential of phytochemical compounds derived from Acalypha indica L. against the DNA gyrase of Staphylococcus aureus using an in silico computational approach.
Lisa Savitri, Kharisul Ihsan, Elfred Rinaldo Kasimo, Rochmad Krissanjaya   +3 more
doaj   +1 more source

Conversion of DNA gyrase into a conventional type II topoisomerase

, 1996
DNA gyrase is unique among topoisomerases in its ability to introduce negative supercoils into closed-circular DNA. We have demonstrated that deletion of the C-terminal DNA-binding domain of the A subunit of gyrase gives rise to an enzyme that cannot ...
Kampranis, S C, Maxwell, A
core   +1 more source

Inhibitory action of exogenous cardiolipin on the bacterial type i and ii dna topoisomerases in vitro

Тонкие химические технологии, 2012
The influence of empty liposomes composed of cardiolipin (lipid which is a component of the bacterial cytoplasmic membrane and eukaryotic internal mitochondrial membrane) on Escherichia coli topoisomerase I and DNA gyrase (topoisomerase II) in vitro was ...
Yu. L. Mikulovich, G. М. Sorokoumova, А. А. Selishcheva, V. I. Shvets   +3 more
doaj  

DNA deformability defines sequence-dependent capture of E. coli gyrase

Bacterial gyrase, unique among type II topoisomerases, introduces negative supercoils into DNA. Mechanistic details of gyrase still must be elucidated because of the complexity of the process and the difficulty in visualizing it.
Eckerty, Ryan, Summers, Silvia, Vayssières, Marlène, Baker, Matthew, Zechiedrich, Lynn, Johnson, Haley, Olson, Wilma, Marechal, Nils, Fogg, Jonathan, Lamour, Valerie   +9 more
core   +1 more source

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors. [PDF]

Front Bioinform
Sahoo CR, Rout M, Paidesetty SK, Dehury B, Bhattacharya D, Pati S.   +5 more
europepmc   +1 more source

A high-throughput fluorescent DNA cleavage assay for discovering bacterial DNA gyrase poisons. [PDF]

Nucleic Acids Res
Dias M, Annamalai T, Otsuka Y, Leng S, Chapagain T, Ferdous S, Shumate J, Scampavia L, Spicer TP, Leng F.   +9 more
europepmc   +1 more source