Direct observation of DNA overwinding by reverse gyrase [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Reverse gyrase resides in bacteria that live in hot conditions. The enzyme further intertwines the double helix of DNA to make it tighter. In biochemical assays, reverse gyrase appears quite inefficient, requiring many enzyme molecules per DNA and yet taking many minutes to wind it up.
Katsunori Yogo +2 more
exaly +4 more sources
In silico analysis of luteolin derivatives as antibacterial agents targeting DNA gyrase and CTX-M-15 extended-spectrum β-lactamase of Escherichia coli [PDF]
Journal of Advanced Pharmaceutical Technology & ResearchLuteolin exhibited antibacterial activity against Escherichia coli and its chemical structure similar to that of ciprofloxacin (CPF) which works by inhibiting DNA gyrase.
Nuzul Wahyuning Diyah +3 more
doaj +2 more sources
Molecules, 2021 Gyrase is a bacterial type IIA topoisomerase that catalyzes negative supercoiling of DNA. The enzyme is essential in bacteria and is a validated drug target in the treatment of bacterial infections.
Dagmar Klostermeier
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Antibiotics, 2022 DNA gyrase and topoisomerase IV are proven to be validated targets in the design of novel antibacterial drugs. In this study, we report the antibacterial evaluation and molecular docking studies of previously synthesized two series of cyclic ...
Neveen M. Saleh +7 more
doaj +1 more source
RNA INTERFERNCE (RNAI) FOR SOME GENES FROM BABESIA BOVIS [PDF]
Research Journal of Applied Biotechnology, 2016 Babesia parasites are responsible for enormous economic losses to the livestock industry worldwide. There is no vaccine available to protect from the infection.
Ikuo Igarashi +2 more
doaj +1 more source
Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase. [PDF]
PLoS ONE, 2017 To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed.
Scott S Walker +20 more
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Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives. [PDF]
PLoS ONE, 2013 A total of 19 novel (3a-3s) N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide analogs were designed, synthesized, and evaluated for biological activities as potential DNA gyrase inhibitors. The results showed that compound 3k can strongly inhibit
Juan Sun +5 more
doaj +1 more source
Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India. [PDF]
PLoS ONE, 2015 Enteric fever is a major cause of morbidity in several parts of the Indian subcontinent. The treatment for typhoid fever majorly includes the fluoroquinolone group of antibiotics.
Manoj Kumar +6 more
doaj +1 more source
The bacteriophage LUZ24 “Igy” peptide inhibits the Pseudomonas DNA gyrase
Cell Reports, 2021 Summary: The bacterial DNA gyrase complex (GyrA/GyrB) plays a crucial role during DNA replication and serves as a target for multiple antibiotics, including the fluoroquinolones.
Jeroen De Smet +9 more
doaj +1 more source
Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor [PDF]
Antimicrobial Agents and Chemotherapy, 1994 We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to 100 micrograms/ml showed no effect on DNA gyrase when linear DNA was used as a substrate.
N, Nakada +3 more
openaire +2 more sources