Results 21 to 30 of about 1,085,040 (311)

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

Vaccines, 2019
This review provides a comparison of the theoretical issues and experimental findings for plasmid DNA and mRNA vaccine technologies. While both have been under development since the 1990s, in recent years, significant excitement has turned to mRNA ...
Margaret A. Liu
semanticscholar   +1 more source

Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Chlamydia trachomatis Biovars

mBio, 2018
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease. C. trachomatis isolates are classified into 2 biovars—lymphogranuloma venereum (LGV) and trachoma—which are ...
Michael John Patton, Chih-Yu Chen, Chunfu Yang, Stuart McCorrister, Chris Grant, Garrett Westmacott, Xin-Yong Yuan, Estela Ochoa, Robert Fariss, William M. Whitmire, John H. Carlson, Harlan D. Caldwell, Grant McClarty   +12 more
doaj   +1 more source

Co-occurrence of blaNDM–1 and mcr-9 in a Conjugative IncHI2/HI2A Plasmid From a Bloodstream Infection-Causing Carbapenem-Resistant Klebsiella pneumoniae

Frontiers in Microbiology, 2021
Spread of the carbapenemase-encoding and mobilized colistin resistance (mcr) genes among Enterobacteriales poses a great threat to global public health, especially when the both genes are transferred by a single plasmid.
Zhou Liu, Xiubing Hang, Xiao Xiao, Wenwen Chu, Xin Li, Yangyang Liu, Yangyang Liu, Yangyang Liu, Xi Li, Qiang Zhou, Jiabin Li, Jiabin Li, Jiabin Li, Jiabin Li   +13 more
doaj   +1 more source

Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli

mBio, 2017
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria.
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, T. Walsh, Jianzhong Shen, Yang Wang   +9 more
semanticscholar   +1 more source

Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance In many clinically important bacteria, antibiotic resistance genes are primarily carried on plasmids. These can spread horizontally between different strains and species.
S. David, Victoria Cohen, S. Reuter, A. Sheppard, Tommaso Giani, J. Parkhill, G. Rossolini, E. Feil, H. Grundmann, D. Aanensen   +9 more
semanticscholar   +1 more source

Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2016
We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.
B. Xavier, C. Lammens, Rohit Ruhal, S. Kumar-Singh, P. Butaye, H. Goossens, S. Malhotra-Kumar   +6 more
semanticscholar   +1 more source

Genome characteristics of the optrA-positive Clostridium perfringens strain QHY-2 carrying a novel plasmid type

mSystems, 2023
Clostridium perfringens is a bacterial species of importance to both public and animal health. The gene optrA is the first gene that confers resistance to the tedizolid, a last-resort antimicrobial agent in human medicine.
Ke Wu, Zhe Li, Mingjin Fang, Yuan Yuan, Edward M. Fox, Yingqiu Liu, Ruichao Li, Li Bai, Wen Zhang, Wei-Min Zhang, Qi Yang, Lingling Chang, Pu Li, Xinglong Wang, Juan Wang, Zengqi Yang   +15 more
doaj   +1 more source

Limited Genetic Diversity of blaCMY-2-Containing IncI1-pST12 Plasmids from Enterobacteriaceae of Human and Broiler Chicken Origin in The Netherlands

Microorganisms, 2020
Distinguishing epidemiologically related and unrelated plasmids is essential to confirm plasmid transmission. We compared IncI1–pST12 plasmids from both human and livestock origin and explored the degree of sequence similarity between plasmids from ...
Evert P.M. den Drijver, Joep J.J.M. Stohr, Jaco J. Verweij, Carlo Verhulst, Francisca C. Velkers, Arjan Stegeman, Marjolein F.Q. Kluytmans-van den Bergh, Jan A.J.W. Kluytmans, i---Health Study Group   +8 more
doaj   +1 more source

Comparative genomic analysis of two novel plasmids from Acidithiobacillus ferrivorans strain PQ33

Revista Peruana de Biología, 2021
Acidithiobacillus ferrivorans is a psychrotolerant acidophile capable of growing and oxidizing ferrous and sulphide substrates at low temperatures. To date, six genomes of this organism have been characterized; however, evidence of a plasmid in this ...
Robert Ccorahua, Anika Eca, Pablo Ramírez, Michel Abanto, Ruth Garcia-de-la-Guarda, Tito Sánchez, Jaime Sánchez-Venegas   +6 more
doaj   +1 more source

Detecting plasmid-mediated dissemination of blaKPC-3 and blaOXA-48-like genes in Enterobacterales across Finnish healthcare organizations using hybrid genome assembly

Frontiers in Microbiology
The spread of carbapenemase-producing Enterobacterales (CPE) is a global concern. While the majority of the CPE outbreaks are due to clonal spread, recent findings highlight the transmission of carbapenemase gene-carrying plasmids across various ...
Meeri Piispa, Meeri Piispa, Anni Vainio, Jani Halkilahti, Outi Lyytikäinen, Kati Räisänen   +5 more
doaj   +1 more source