Results 11 to 20 of about 145,569 (114)

Calcium-responsive plasmid copy number regulation is dependent on discrete YopD domains in Yersinia pseudotuberculosis

, 2023
Yersinia pathogenicity depends mainly on a Type III Secretion System (T3SS) responsible for translocating effector proteins into the eukaryotic target cell cytosol. The T3SS is encoded on a 70 kb, low copy number virulence plasmid, pYV.
Wang, Helen, Engling, Pit,, Tifaine Héchard, Edgren, Tomas,, Engling, Pit, Tomas Edgren, Francis, Matthew,, Francis, Matthew, Pit Engling, Héchard, Tifaine, Edgren, Tomas, Dersch, Petra,, Wang, Helen,, Héchard, Tifaine,, Helen Wang, Dersch, Petra, Matthew Francis, Petra Dersch   +17 more
core   +1 more source

DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations

Molecular Therapy: Nucleic Acids, 2016
Adeno-associated viral (AAV) vectors are considered as one of the most promising delivery systems in human gene therapy. In addition, AAV vectors are frequently applied tools in preclinical and basic research. Despite this success, manufacturing pure AAV
Maria Schnödt, Marco Schmeer, Barbara Kracher, Christa Krüsemann, Laura Escalona Espinosa, Anja Grünert, Thomas Fuchsluger, Anja Rischmüller, Martin Schleef, Hildegard Büning   +9 more
doaj   +1 more source

Prevalence of bla_KPC-2, bla_KPC-3 and bla_KPC-30—Carrying Plasmids in Klebsiella pneumoniae Isolated in a Brazilian Hospital

Pathogens, 2021
Klebsiella pneumoniae carbapenemase (KPC) actively hydrolyzes carbapenems, antibiotics often used a last-line treatment for multidrug-resistant bacteria. KPC clinical relevance resides in its widespread dissemination.
Letícia B. Migliorini, Romário O. de Sales, Paula C. M. Koga, Andre M. Doi, Anja Poehlein, Alexandra R. Toniolo, Fernando G. Menezes, Marines D. V. Martino, Ana C. Gales, Holger Brüggemann, Patricia Severino   +10 more
doaj   +1 more source

Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant, qnr-Carrying Escherichia coli Isolated from the German Food Chain in 2017

Microorganisms, 2021
Fluoroquinolones are the highest priority, critically important antimicrobial agents. Resistance development can occur via different mechanisms, with plasmid-mediated quinolone resistance (PMQR) being prevalent in the livestock and food area. Especially,
Katharina Juraschek, Carlus Deneke, Silvia Schmoger, Mirjam Grobbel, Burkhard Malorny, Annemarie Käsbohrer, Stefan Schwarz, Diana Meemken, Jens Andre Hammerl   +8 more
doaj   +1 more source

Plasmid-mediated restriction evasion mechanisms

, 1999
Plasmid ColIb-P9 (Incll) encodes mechanisms which allow it to avoid destruction by type I and type II restriction enzymes during transfer by conjugation between strains of Escherichia coli. A genetic system was developed to analyse these mechanisms.
Nicola Jayne. Althorpe (7679351)
core   +4 more sources

High-Yield Expression and Purification of Recombinant Influenza Virus Proteins from Stably-Transfected Mammalian Cell Lines

Vaccines, 2020
Influenza viruses infect millions of people each year, resulting in significant morbidity and mortality in the human population. Therefore, generation of a universal influenza virus vaccine is an urgent need and would greatly benefit public health ...
Jeffrey W. Ecker, Greg A. Kirchenbaum, Spencer R. Pierce, Amanda L. Skarlupka, Rodrigo B. Abreu, R. Ethan Cooper, Dawn Taylor-Mulneix, Ted M. Ross, Giuseppe A. Sautto   +8 more
doaj   +1 more source

Plasmid-Mediated Antibiotic Resistant Escherichia coli in Sarawak Rivers and Aquaculture Farms, Northwest of Borneo

Antibiotics, 2021
Background: The emergence of plasmid-mediated antibiotic resistance in Escherichia coli in water resources could pose a serious threat to public health. The study aims to investigate the dispersion of plasmid-mediated antibiotic-resistant E.
Samuel Lihan, Sai Y. Lee, Seng C. Toh, Sui S. Leong   +3 more
doaj   +1 more source

Multiple pathways of plasmid DNA transfer in Helicobacter pylori [PDF]

, 2012
Many Helicobacter pylori (Hp) strains carry cryptic plasmids of different size and gene content, the function of which is not well understood. A subgroup of these plasmids (e.g.
Haas, Rainer, Rainer Haas, Lea Holsten (133951), Wolfgang Fischer (133965), Holsten, Lea, Stefanie Rohrer (133947), Rohrer, Stefanie, Rainer Haas (81562), Weiss, Evelyn, Lea Holsten, Mohammed Benghezal, Evelyn Weiss (133955), Mohammed Benghezal (133961), Stefanie Rohrer, Wolfgang Fischer, Benghezal, Mohammed, Evelyn Weiss, Fischer, Wolfgang, Weiss Evelyn, Benghezal Mohammed, Rohrer Stefanie, Fischer Wolfgang, Holsten Lea, Haas Rainer   +23 more
core   +2 more sources

Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Chlamydia trachomatis Biovars

mBio, 2018
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease. C. trachomatis isolates are classified into 2 biovars—lymphogranuloma venereum (LGV) and trachoma—which are ...
Michael John Patton, Chih-Yu Chen, Chunfu Yang, Stuart McCorrister, Chris Grant, Garrett Westmacott, Xin-Yong Yuan, Estela Ochoa, Robert Fariss, William M. Whitmire, John H. Carlson, Harlan D. Caldwell, Grant McClarty   +12 more
doaj   +1 more source

Co-occurrence of blaNDM–1 and mcr-9 in a Conjugative IncHI2/HI2A Plasmid From a Bloodstream Infection-Causing Carbapenem-Resistant Klebsiella pneumoniae

Frontiers in Microbiology, 2021
Spread of the carbapenemase-encoding and mobilized colistin resistance (mcr) genes among Enterobacteriales poses a great threat to global public health, especially when the both genes are transferred by a single plasmid.
Zhou Liu, Xiubing Hang, Xiao Xiao, Wenwen Chu, Xin Li, Yangyang Liu, Yangyang Liu, Yangyang Liu, Xi Li, Qiang Zhou, Jiabin Li, Jiabin Li, Jiabin Li, Jiabin Li   +13 more
doaj   +1 more source