Frontiers in Microbiology, 2022 Microorganisms have developed many strategies in the process of long-term defense against external attacks, one of which is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological ...
Yuqiao Zhou +10 more
doaj +1 more source
Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer
Science, 2019 A race against time Clinically relevant antimicrobial resistance is largely spread via plasmids that disperse among bacteria during conjugation. How quickly can a resistance gene be expressed after transfer?
S. Nolivos +5 more
semanticscholar +1 more source
Transformation of the Methylotrophic Actinomycete Amycolatopis methanolica with Plasmid DNA: Stimulatory Effect of a pMEA300-Encoded Gene [PDF]
, 1995 Amycolatopsis methanolica contains a 13.29-kb plasmid (pMEA300) present both in the free state and integrated at a unique genomic location. A pMEA300-free derivative (strain WV1) was selected, allowing further analysis of pMEA300-encoded functions. Whole
Dijkhuizen, L., +2 more
core +2 more sources
The gossip paradox: Why do bacteria share genes?
Mathematical Biosciences and Engineering, 2022 Bacteria, in contrast to eukaryotic cells, contain two types of genes: chromosomal genes that are fixed to the cell, and plasmids, smaller loops of DNA capable of being passed from one cell to another.
Alastair D. Jamieson-Lane, Bernd Blasius
doaj +1 more source
Eigensolutions and spectral analysis of a model for vertical gene transfer of plasmids [PDF]
, 2018 Plasmids are autonomously replicating genetic elements in bacteria. At cell division plasmids are distributed among the two daughter cells. This gene transfer from one generation to the next is called vertical gene transfer. We study the dynamics of a bacterial population carrying plasmids and are in particular interested in the long-time distribution ...
arxiv +1 more source
Plasmid detection and assembly in genomic and metagenomic data sets
Genome Research, 2019 Although plasmids are important for bacterial survival and adaptation, plasmid detection and assembly from genomic, let alone metagenomic, samples remain challenging.
D. Antipov +3 more
semanticscholar +1 more source
Expression of Green Fluorescence Protein (GFP) in Zebrafish Muscle through Injection: A Gene Therapy Model [PDF]
, 2008 Expression of the target gene is important for gene therapy. Presently, localized transgenesis is used for gene therapy which can be achieved by a target gene expression. Here, we have reported the plasmid mediated gene therapy to zebrafish model.
C. H. Hsu +4 more
core +2 more sources
Asymmetrical inheritance of plasmids depends on dynamic cellular geometry and volume exclusion effects [PDF]
, 2015 The asymmetrical inheritance of plasmid DNA, as well as other cellular components, has been shown to be involved in replicative aging. In Saccharomyces cerevisiae, there is an ongoing debate regarding the mechanisms underlying this important asymmetry. Currently proposed models suggest it is established via diffusion, but differ on whether a diffusion ...
arxiv +1 more source
Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance
Nature Communications, 2019 Plasmid acquisition is an important mechanism of rapid adaptation and niche expansion in prokaryotes. Positive selection for plasmid-coded functions is a major driver of plasmid evolution, while plasmids that do not confer a selective advantage are ...
Tanita Wein +3 more
semanticscholar +1 more source
First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus
Frontiers in Cellular and Infection Microbiology, 2022 We describe the identification of a methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus. The isolate (1801221) was characterized as t6675-ST2250-SCCmecIVc, and whole-genome sequencing revealed that the isolate possessed two ...
Adebayo Osagie Shittu +7 more
doaj +1 more source