Results 61 to 70 of about 1,502,313 (400)

Genetic Insights on Meropenem Resistance Concerning Klebsiella pneumoniae Clinical Isolates

Life
The transferable genetic elements are associated with the dissemination of virulence determinants amongst Klebsiella pneumoniae. Thus, we assessed the correlated antimicrobial resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates ...
Fathy M. Elkady, Bahaa M. Badr, Abdel-Aty E. Alfeky, Mohammed S. Abdulrahman, Amr H. Hashem, Abdulaziz A. Al-Askar, Gehad AbdElgayed, Hany R. Hashem   +7 more
doaj   +1 more source

A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition

Frontiers in Microbiology, 2020
Toxin/antitoxin (TA) systems are present in most prokaryote genomes. Toxins are almost exclusively proteins that reduce metabolism (but do not cause cell death), and antitoxins are either RNA or proteins that counteract the toxin or the RNA that encodes ...
Sooyeon Song, Thomas K. Wood
doaj   +1 more source

First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus

Frontiers in Cellular and Infection Microbiology, 2022
We describe the identification of a methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus. The isolate (1801221) was characterized as t6675-ST2250-SCCmecIVc, and whole-genome sequencing revealed that the isolate possessed two ...
Adebayo Osagie Shittu, Adebayo Osagie Shittu, Franziska Layer-Nicolaou, Birgit Strommenger, Minh-Thu Nguyen, Stefan Bletz, Alexander Mellmann, Frieder Schaumburg   +7 more
doaj   +1 more source

Insights into a Novel blaKPC-2-Encoding IncP-6 Plasmid Reveal Carbapenem-Resistance Circulation in Several Enterobacteriaceae Species from Wastewater and a Hospital Source in Spain [PDF]

, 2017
Untreated wastewater, particularly from hospitals and other healthcare facilities, is considered to be a reservoir for multidrug-resistant bacteria.
Cantón, Rafael, Chakraborty, Trinad, Dominguez, Lucas, Falgenhauer, Linda, Imirzalioglu, Can, Lazaro-Perona, Fernando, Mingorance, Jesús, Valverde, Aránzazu, Yao, Yancheng   +8 more
core   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2

Frontiers in Immunology
Nucleic acid vaccine approaches have proven successful in the context of the SARS-CoV-2 pandemic, however challenges with delivery remain. Here we describe PlaCCine, a DNA-based vaccine platform that utilizes a device- and vector-free chemical delivery ...
Subeena Sood, Ebony N. Gary, Majed Matar, Jessica Kim, Casey E. Hojecki, Bryce Warner, Robert Vendramelli, Thang Truong, Alanna Smith, Jennifer Rice, Jeff Sparks, Michael DeSalvo, John Henderson, Joseph A. Rogers, Ankur Sharma, Laurent Pessaint, Carlo A. Iavarone, Darwyn Kobasa, Jean D. Boyer, Stacy Lindborg, Khursheed Anwer   +20 more
doaj   +1 more source

Plasmid-Encoded Multidrug Resistance of Salmonella typhi and some Enteric Bacteria in and around Kolkata, India: A Preliminary Study [PDF]

, 2005
The present study investigates the occurrence of R-plasmid in Salmonella typhi isolates from enteric fever cases in and around Kolkata (1991-2001), India following in vitro conjugation experiments, isolation of plasmid DNAs and agarose gel ...
Mandal, Mr. Shyamapada, Mandal, Ms. Manisha Deb, Pal, Dr. Nishith Kumar   +2 more
core  

Effect of temperature, pH and plasmids on in vitro biofilm formation in Escherichia coli [PDF]

, 2018
Acid resistance (AR) in Escherichia coli is an important trait that protects this microorganism from the deleterious effect of low-pH environments. Reports on biofilm formation in E.
DE BIASE, Daniela, Mathlouthi, Ahmed, Pennacchietti, Eugenia   +2 more
core   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source