Results 51 to 60 of about 1,194,207 (363)

Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens

The ISME Journal
Antimicrobial resistance is a major threat for public health. Plasmids play a critical role in the spread of antimicrobial resistance via horizontal gene transfer between bacterial species.
Xiaolong Wang, Hanhui Zhang, Shenbo Yu, Donghang Li, M. Gillings, Hongqiang Ren, Daqing Mao, Jianhua Guo, Yi Luo   +8 more
semanticscholar   +1 more source

Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context.

Trends in Microbiology, 2018
Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply increase mortality risk in critically ill patients.
Á. San Millán
semanticscholar   +1 more source

Characterization of a novel Phietavirus genus bacteriophage and its potential for efficient transfer of modified shuttle plasmids to Staphylococcus aureus strains of different clonal complexes

Microbiology Spectrum
Staphylococcus aureus is a significant human pathogen responsible for various nosocomial and community-acquired infections, leading to considerable morbidity and mortality worldwide. Temperate bacteriophages contribute to its virulence and facilitate the
Łukasz Kałuski, Emil Stefańczyk, Aleksandra Głowacka-Rutkowska, Jan Gawor, Joanna Empel, Monika Orczykowska-Kotyna, Aleksandra Szczypkowska, Karolina Żuchniewicz, Robert Gromadka, Małgorzata Łobocka   +9 more
doaj   +1 more source

KPC-2-Producing Carbapenem-Resistant Klebsiella pneumoniae of the Uncommon ST29 Type Carrying OXA-926, a Novel Narrow-Spectrum OXA β-Lactamase

Frontiers in Microbiology, 2021
We isolated and characterized a carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical strain from blood carrying a novel blaOXA gene, blaOXA–926, and belonging to ST29, an uncommon CRKP type. The strain, 130002, was genome sequenced using both short-
Lina Liu, Yu Feng, Li Wei, Yuling Xiao, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +7 more
doaj   +1 more source

Genetic Insights on Meropenem Resistance Concerning Klebsiella pneumoniae Clinical Isolates

Life
The transferable genetic elements are associated with the dissemination of virulence determinants amongst Klebsiella pneumoniae. Thus, we assessed the correlated antimicrobial resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates ...
Fathy M. Elkady, Bahaa M. Badr, Abdel-Aty E. Alfeky, Mohammed S. Abdulrahman, Amr H. Hashem, Abdulaziz A. Al-Askar, Gehad AbdElgayed, Hany R. Hashem   +7 more
doaj   +1 more source

A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition

Frontiers in Microbiology, 2020
Toxin/antitoxin (TA) systems are present in most prokaryote genomes. Toxins are almost exclusively proteins that reduce metabolism (but do not cause cell death), and antitoxins are either RNA or proteins that counteract the toxin or the RNA that encodes ...
Sooyeon Song, Thomas K. Wood
doaj   +1 more source

First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus

Frontiers in Cellular and Infection Microbiology, 2022
We describe the identification of a methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus. The isolate (1801221) was characterized as t6675-ST2250-SCCmecIVc, and whole-genome sequencing revealed that the isolate possessed two ...
Adebayo Osagie Shittu, Adebayo Osagie Shittu, Franziska Layer-Nicolaou, Birgit Strommenger, Minh-Thu Nguyen, Stefan Bletz, Alexander Mellmann, Frieder Schaumburg   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Complete nucleotide sequence of pH11, an IncHI2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical Klebsiella pneumoniae isolate

, 2016
The complete 284,628 bp sequence of pH11, an IncHI2 plasmid, was determined through single-molecule, real-time (SMRT) sequencing. Harbored by a clinical Klebsiella pneumoniae strain H11, and isolated in Beijing, this plasmid contains multiple antibiotic ...
Zhai, Yao, Kang, Yu, Yu, Haiying, Zhang, Zhao, Hu, Songnian, He, Zilong, Wang, Jianfeng, Du, Pengcheng, Gao, Zhancheng   +8 more
core   +1 more source

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2

Frontiers in Immunology
Nucleic acid vaccine approaches have proven successful in the context of the SARS-CoV-2 pandemic, however challenges with delivery remain. Here we describe PlaCCine, a DNA-based vaccine platform that utilizes a device- and vector-free chemical delivery ...
Subeena Sood, Ebony N. Gary, Majed Matar, Jessica Kim, Casey E. Hojecki, Bryce Warner, Robert Vendramelli, Thang Truong, Alanna Smith, Jennifer Rice, Jeff Sparks, Michael DeSalvo, John Henderson, Joseph A. Rogers, Ankur Sharma, Laurent Pessaint, Carlo A. Iavarone, Darwyn Kobasa, Jean D. Boyer, Stacy Lindborg, Khursheed Anwer   +20 more
doaj   +1 more source