Results 191 to 200 of about 680,206 (303)

Molecular characteristics of KPC-producing <i>Klebsiella pneumoniae</i> isolates from children and adults in Kunming. [PDF]

Microbiol Spectr
Wang W, Qian J, Zheng R, Liu H, Jian X, Zhao J, Liang Y, Bao L, Su M, Chen Y, Hang Y, Wu J, You X, Shen A, Han D, Jiang L, Liu X.   +16 more
europepmc   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Multi-species plasmids and <i>K. pneumoniae</i> clonal spread contribute to <i>bla</i> _NDM outbreak across seven UK healthcare sites. [PDF]

JAC Antimicrob Resist
Duggan C, Brookfield C, Lawrie D, Owen V, Neal T, Cruise J, Fraser AJ, Kelly L, Graf FE, Cantillon D, Lewis JM, Edwards T, Heinz E.   +12 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Protocol for telomere-to-telomere assembly of Borrelia genomes using a hybrid method. [PDF]

STAR Protoc
Amin AB, Ibarra-Meneses AV, Blanchette M, Fernandez-Prada C, Langlais D.   +4 more
europepmc   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Genomic Insight into <i>Escherichia coli</i> Bloodstream Infections at a Tertiary Hospital in Shanghai: Predominance, Genetic Diversity, and Plasmid-Associated Virulence of CC131 and CC14. [PDF]

Antibiotics (Basel)
Tulufu Y, Wu Q, Xiao S, Wang Y, Wang J, Han L, Tang J.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

National genomic surveillance of carbapenemase-producing <i>Escherichia coli</i> isolates in Slovenia, January 1st-December 31st 2023. [PDF]

Front Public Health
Pirs M, Kramar U, Triglav T, Strašek Smrdel K, Celar Šturm A, Bezjak L, Janezic S.   +6 more
europepmc   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source