Results 51 to 60 of about 317,079 (354)

Plasmodium knowlesi infecting humans in Southeast Asia: What's next?

PLoS Neglected Tropical Diseases, 2020
Plasmodium knowlesi, a simian malaria parasite, has been in the limelight since a large focus of human P. knowlesi infection was reported from Sarawak (Malaysian Borneo) in 2004.
N. K. Jeyaprakasam, J. Liew, V. Low, Wan-Yusoff Wan-Sulaiman, I. Vythilingam   +4 more
semanticscholar   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Plasmodium knowlesi Malaria in Sabah, Malaysia, 2015–2017: Ongoing Increase in Incidence Despite Near-elimination of the Human-only Plasmodium Species

Clinical Infectious Diseases, 2019
Background Malaysia aims to eliminate malaria by 2020. However, while cases of Plasmodium falciparum and Plasmodium vivax have decreased substantially, the incidence of zoonotic malaria from Plasmodium knowlesi continues to increase, presenting a major ...
Daniel J Cooper, G. Rajahram, T. William, J. Jelip, R. Mohammad, Joseph Benedict, Danshy A Alaza, E. Malacova, T. Yeo, M. Grigg, N. Anstey, Bridget E. Barber   +11 more
semanticscholar   +1 more source

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Post‐Artesunate Delayed Hemolysis: Anything That Can Go Wrong Will Go Wrong—Murphy's Law

Clinical Case Reports
In patients presenting with post‐malarial anemia following intravenous artesunate treatment, post‐artesunate delayed hemolysis should be considered in the differential diagnosis, even in endemic settings.
Beliza Chemutai, Muhammed Omar Ali, Jaimin Vinod Varsani, Derrick Bary Abila, Denis Can Odonga, Paska Apiyo, Felix Bongomin   +6 more
doaj   +1 more source

The αTSR Domain of Plasmodium Circumsporozoite Protein Bound Heparan Sulfates and Elicited High Titers of Sporozoite Binding Antibody After Displayed by Nanoparticles

International Journal of Nanomedicine, 2023
Ming Xia,1 Frank Vago,2 Ling Han,3 Pengwei Huang,1 Linh Nguyen,3 Geert-Jan Boons,4– 6 John S Klassen,3 Wen Jiang,2 Ming Tan1,7 1Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; 2Department of Biological
Xia M, Vago F, Han L, Huang P, Nguyen L, Boons GJ, Klassen JS, Jiang W, Tan M   +8 more
doaj  

Biochemical Responses of Anopheles spp. Larvae to a Novel Brazilian BR101 Bacillus thuringiensis var. israelensis Formulation: Oxidative Stress, Detoxification Enzymes, and Safety for Nontarget Notonectidae and Gerridae Aquatic Insects

Chemistry &Biodiversity, EarlyView.
Bti BR101 exhibits strong larvicidal activity against Anopheles larvae spp., with dose‐dependent mortality and LC50 of 3.13 µg/mL. Bti increases ROS, lipid and protein oxidation, and activates antioxidant enzymes (SOD, CAT, GPx) and detoxification pathways (MFO and esterases), indicating moderate oxidative stress.
Izabel Cristina de Oliveira Bentes, Dayane Dantas Abensour, Maria Luiza Lima da Costa, Raquel Telles de Moreira Sampaio, Leticia Bernadete da Silva, Francisco Augusto da Silva Ferreira, Cláudia Patrícia da Silva Tavares, Hergen Vieira de Souza, Francisco de Assis Marque, Mário Antonio Navarro da Silva, Eduarda Andrade de Lima, Gislayne Trindade Vilas‐Boas, João Antonio Cyrino Zequi, André Correa de Oliveira, Rosemary Aparecida Roque   +14 more
wiley   +1 more source

Nuevas rutas de permeabilidad en Plasmodium falciparum: consideraciones como blanco farmacológico y avances de los potenciales inhibidores

Actualidades Biológicas, 2021
Con base en la persistencia de los casos de malaria, dados por múltiples razones, entre las cuales se encuentra la resistencia de Plasmodium falciparum a los antimálaricos establecidos para su tratamiento, surge la necesidad de encontrar nuevos ...
Yeison Castañeda-Agudelo, Adriana Pabón-Vidal   +1 more
doaj   +1 more source

Knowledge, attitude, and adherence to malaria control guidelines and the prevalence of Plasmodium species infection in localities across transmission and ecological zones in Cameroon [PDF]

, 2023
Livinus N. Tangi, Marcelus U. Ajonina, Marcel N. Moyeh, F. Hanesh, Vincent N. Ntui, Pilate N. Kwi, Eric C. T. Toussi, Mary Progress S. Fung, FohTella Fah, Joel M. Mayaba, Franklin T. Formilack, Veronica N. Ntasin, Theobald Mue Nji, Emmanuel V. Yenshu, Eric Achidi, Alfred Amambua‐Ngwa, Tobias O. Apinjoh   +16 more
openalex   +1 more source