BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]
, 2014 While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P. +11 more
core +1 more source
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate +4 more
core +2 more sources
Evidence of Massive Horizontal Gene Transfer Between Humans and Plasmodium vivax [PDF]
, 2011 The horizontal transfer of DNA between different organisms is a major force shaping the genomes of prokaryotes, but is considered to have a minor role in eukaryotes, with only a handful of known examples, mostly of limited size.
Daniel Z. Bar
core +2 more sources
Effect of a+ -thalassaemia on episodes of fever due to malaria and other causes: a communitybased cohort study in Tanzania [PDF]
, 2011 Background It is controversial to what degree a+-thalassaemia protects against episodes of uncomplicated malaria and febrile disease due to infections other than Plasmodium. Methods In Tanzania, in children aged 6-60 months and height-for-age z-score
Baidjoe, A.Y. +7 more
core +5 more sources
Periodontology 2000, EarlyView., 2023 Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera +4 more
wiley +1 more source
A review on malaria eradication: what hope for Nigeria?
Journal of Applied Sciences and Environmental Management, 2016 Malaria and its transmitting vectors are household names. Malaria which helped Africa from the venomous fangs of colonialism has turned to be the bane of development in tropical countries including Nigeria.
E.C. Amadi
doaj +1 more source
eLife, 2023 Iron-sulfur clusters (FeS) are ancient and ubiquitous protein cofactors that play fundamental roles in many aspects of cell biology. These cofactors cannot be scavenged or trafficked within a cell and thus must be synthesized in any subcellular ...
Russell P Swift +4 more
doaj +1 more source
Exploiting Environmental Computation in a Multi-Agent Model of Slime Mould
, 2015 Very simple organisms, such as the single-celled amoeboid slime mould Physarum polycephalum possess no neural tissue yet, despite this, are known to exhibit complex biological and computational behaviour.
Jones, Jeff
core +1 more source
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa [PDF]
, 2007 Objective Artemether-lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele.
Barnes +21 more
core +2 more sources
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source