Results 51 to 60 of about 263,948 (264)

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial

npj Vaccines
The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface to mediate invasion.
Francisco J. Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M. Hou, Sarah E. Silk, Jordan R. Barrett, Carolyn M. Nielsen, Jenny M. Reimer, Paushali Mukherjee, Virander S. Chauhan, Angela M. Minassian, Simon J. Draper, Chetan E. Chitnis   +17 more
doaj   +1 more source

Plasmodium telomere maintenance: uncovering the Achilles’ heel for novel antimalarials

Frontiers in Cellular and Infection Microbiology
This review examines the potential of disrupting telomere maintenance in Plasmodium as a novel antimalarial strategy. Telomeres are repetitive DNA–protein structures located at chromosome termini, where they preserve genome stability and protect against ...
Theophilus N. Wakai, Theophilus N. Wakai, Dorathy O. Anzaku, Dorathy O. Anzaku, Israel S. Afolabi   +4 more
doaj   +1 more source

Possible evidence of gluconeogenesis in Plasmodium- Infected children in relationship with the parasite density

Biomedical and Biotechnology Research Journal, 2020
Background: Gluconeogenesis is stimulated by low blood glucose to maintain the glucose level; it involves lipolysis (breaking down of triglycerides), release of cortisol, and production of glycerol which can be converted into glucose.
Mathew Folaranmi Olaniyan, Tolulope Busayo Ojediran, Shedarck Gbenga Olayinka   +2 more
doaj   +1 more source

Morphogenesis of Plasmodium zoites is uncoupled from tensile strength. [PDF]

, 2013
A shared feature of the motile stages (zoites) of malaria parasites is a cortical cytoskeletal structure termed subpellicular network (SPN), thought to define and maintain cell shape.
Tremp, Annie Z, Dessens, Johannes T, Carter, Victoria, Saeed, Sadia   +3 more
core   +1 more source

Glutaredoxine reduzieren schnell Glutathionhydroper‐ und Glutathionpolysulfide

Angewandte Chemie, EarlyView.
Glutaredoxine (Grx) reduzieren Glutathionpolysulfide (GSSnSG) schnell zu Glutathionhydroper/polysulfiden (GSSnH) oder GSSnH zu Wasserstoff(poly)sulfiden (H2Sn). Die Reduktion glutathionylierter Grx durch reduziertes Glutathion (GSH) liefert Glutathiondisulfid (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

A Cross-Sectional Study of Malarial Patients in District Faisalabad, Pakistan: Frequency of Infection, Species Distribution, and Diagnostic Efficiency Comparison

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Malarial infection, caused by Plasmodium parasites transmitted by female Anopheles mosquito, is still a serious public health concern, especially in endemic areas such as Sub-Saharan Africa and Pakistan. The study aims to investigate the
Rashid Ali, Muhammad Asrar, Salma Sultana, Amna Sajjad   +3 more
doaj   +1 more source

Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections

Cell Reports, 2020
Summary: Gut microbiota composition is associated with human and rodent Plasmodium infections, yet the mechanism by which gut microbiota affects the severity of malaria remains unknown.
Morgan L. Waide, Rafael Polidoro, Whitney L. Powell, Joshua E. Denny, Justin Kos, David A. Tieri, Corey T. Watson, Nathan W. Schmidt   +7 more
doaj   +1 more source

Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells [PDF]

, 2009
Parasite infection can lead to alterations in the permeability of host plasma membranes. Presented here is the first demonstration that this phenomenon occurs in Plasmodium‐infected liver cells.
Staines, Henry M., Marques, Catarina A., Krishna, Sanjeev, Mota, Maria M., Derbyshire, Elvira T., Marques, CA, Prudêncio, M, Mota, MM, Staines, HM, Prudêncio, Miguel, Krishna, S, Derbyshire, ET   +11 more
core   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source