Results 51 to 60 of about 322,747 (249)

Possible evidence of gluconeogenesis in Plasmodium- Infected children in relationship with the parasite density

Biomedical and Biotechnology Research Journal, 2020
Background: Gluconeogenesis is stimulated by low blood glucose to maintain the glucose level; it involves lipolysis (breaking down of triglycerides), release of cortisol, and production of glycerol which can be converted into glucose.
Mathew Folaranmi Olaniyan, Tolulope Busayo Ojediran, Shedarck Gbenga Olayinka   +2 more
doaj   +1 more source

An ultrasensitive reverse transcription polymerase chain reaction assay to detect asymptomatic low-density Plasmodium falciparum and Plasmodium vivax infections in small volume blood samples. [PDF]

, 2015
BackgroundHighly sensitive, scalable diagnostic methods are needed to guide malaria elimination interventions. While traditional microscopy and rapid diagnostic tests (RDTs) are suitable for the diagnosis of symptomatic malaria infection, more sensitive ...
Adams, Matthew, Han, Kay Thwe, Han, Zay Yar, Hlaing, Tin Maung, Huang, Fang, Johnson, Nicole Eddington, Joshi, Sudhaunshu N, Mbambo, Gillian, Mu, Amy Z, Nyunt, Myaing M, Oo, Khine Zaw, Plowe, Christopher V, Richards, Adam K, Roemmich, Shay M, Shrestha, Biraj, Strauss, Kathy A, Thura, Si   +16 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial

npj Vaccines
The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface to mediate invasion.
Francisco J. Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M. Hou, Sarah E. Silk, Jordan R. Barrett, Carolyn M. Nielsen, Jenny M. Reimer, Paushali Mukherjee, Virander S. Chauhan, Angela M. Minassian, Simon J. Draper, Chetan E. Chitnis   +17 more
doaj   +1 more source

Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections

Cell Reports, 2020
Summary: Gut microbiota composition is associated with human and rodent Plasmodium infections, yet the mechanism by which gut microbiota affects the severity of malaria remains unknown.
Morgan L. Waide, Rafael Polidoro, Whitney L. Powell, Joshua E. Denny, Justin Kos, David A. Tieri, Corey T. Watson, Nathan W. Schmidt   +7 more
doaj   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Plasmodium telomere maintenance: uncovering the Achilles’ heel for novel antimalarials

Frontiers in Cellular and Infection Microbiology
This review examines the potential of disrupting telomere maintenance in Plasmodium as a novel antimalarial strategy. Telomeres are repetitive DNA–protein structures located at chromosome termini, where they preserve genome stability and protect against ...
Theophilus N. Wakai, Theophilus N. Wakai, Dorathy O. Anzaku, Dorathy O. Anzaku, Israel S. Afolabi   +4 more
doaj   +1 more source

Spleen Infarction in Plasmodium Infection [PDF]

Liaquat National Journal of Primary Care
Dear Editor, Malaria is a zoonosis causing public health problems, and more than 600,000 deaths yearly mainly younger; splenic infarction or rupture are rarely described [1- 5].
Vitorino Modesto dos Santos, Andressa Plaça Tedeschi, Julia Campos Modesto   +2 more
doaj   +1 more source

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

eLife, 2020
The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle.
Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, Sean T Prigge   +7 more
doaj   +1 more source