Results 51 to 60 of about 176,373 (221)

Inflammatory response, plasma albumin, creatinine, alanine aminotransferase, and packed cell volume in relationship with the degree of anemia and gestational age in HbAA anemic pregnant women

Biomedical and Biotechnology Research Journal, 2021
Background: Anemia in pregnancy which may be mild, moderate, or severe is a common physiological disorder that can lead to poor pregnancy outcome which may be primary or secondary to problems associated with hepatic, renal, and immune system which may be
Mathew Folaranmi Olaniyan, Musa Abidemi Muhibi, Kehinde Abiola Babatunde   +2 more
doaj   +1 more source

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, EarlyView.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

A small mitochondrial protein present in myzozoans is essential for malaria transmission [PDF]

Open Biology, 2016
Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced mitochondrial genome and divergent metabolic processes.
Dennis Klug, Gunnar R. Mair, Friedrich Frischknecht, Ross G. Douglas   +3 more
doaj   +1 more source

Structural insights into Plasmodium PPIases

Frontiers in Cellular and Infection Microbiology, 2022
Malaria is one of the most prevalent infectious diseases posing a serious challenge over the years, mainly owing to the emergence of drug-resistant strains, sparking a need to explore and identify novel protein targets.
Sreekanth Rajan, Ho Sup Yoon, Ho Sup Yoon, Ho Sup Yoon   +3 more
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Physiological, environmental, and life-history drivers of haemosporidian infections in non-passerine birds from a rehabilitation center

Frontiers in Parasitology
IntroductionPathogens and parasites play a crucial role in shaping ecological and evolutionary processes, influencing the behavior, physiology, and survival of their hosts across diverse ecosystems.
Lis Marques de Carvalho e Vieira, Victor Aguiar de Souza Penha, Kevin J. McGraw, Amanda Vitória Dornelas da Silva, Erika Martins Braga   +4 more
doaj   +1 more source

The αTSR Domain of Plasmodium Circumsporozoite Protein Bound Heparan Sulfates and Elicited High Titers of Sporozoite Binding Antibody After Displayed by Nanoparticles

International Journal of Nanomedicine, 2023
Ming Xia,1 Frank Vago,2 Ling Han,3 Pengwei Huang,1 Linh Nguyen,3 Geert-Jan Boons,4– 6 John S Klassen,3 Wen Jiang,2 Ming Tan1,7 1Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; 2Department of Biological
Xia M, Vago F, Han L, Huang P, Nguyen L, Boons GJ, Klassen JS, Jiang W, Tan M   +8 more
doaj  

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Antimalarial potential of Kerala Ayurvedic Water “Pathimugam”

Journal of Vector Borne Diseases
Background & objectives: The persistent threat of drug resistant malaria demands new cures. Low prevalence of malaria in the Indian state of Kerala compared with other proximal states led us to explore if there is any traditional practice in Kerala which
Naveen Kumar Kaushik, Dinkar Sahal
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source