Results 61 to 70 of about 258,281 (284)

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase [PDF]

, 2011
Background Plasmodium falciparum sporozoites injected by mosquitoes into the blood rapidly enter liver hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte.
Piacentini Mauro, Rodolfo, Carlo, Giuseppina Di Giacomo, Doerig Christian, Di Giacomo, Giuseppina, Piacentini, Mauro, Lanar David E, William S Nicoll, Di Giacomo, G, Nicoll, W.S., Doerig, C., Hollingdale, M.R., David E Lanar, Sacci, JB, Sacci, John, John B Sacci, Piacentini, M, Zoe JM Holland, Michael R Hollingdale, Rodolfo, C., Lanar, D.E., Nicoll William S, Mauro Piacentini, Sacci John B, Doerig, Christian, Lanar, DE, Sacci, J.B., Hollingdale Michael R, Rodolfo Carlo, Hollingdale, MR, Rodolfo, C, Holland, Zoe, Lanar, David, Christian Doerig, Holland Zoe JM, Holland, Z.J.M., Carlo Rodolfo, Di Giacomo Giuseppina, Holland, ZJ, Nicoll, William, Nicoll, WS, Doerig, C, Hollingdale, Michael   +42 more
core   +1 more source

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

Post‐Artesunate Delayed Hemolysis: Anything That Can Go Wrong Will Go Wrong—Murphy's Law

Clinical Case Reports
In patients presenting with post‐malarial anemia following intravenous artesunate treatment, post‐artesunate delayed hemolysis should be considered in the differential diagnosis, even in endemic settings.
Beliza Chemutai, Muhammed Omar Ali, Jaimin Vinod Varsani, Derrick Bary Abila, Denis Can Odonga, Paska Apiyo, Felix Bongomin   +6 more
doaj   +1 more source

Sex ratios in the rodent malaria parasite, Plasmodium chabaudi [PDF]

, 2003
The sex ratios of malaria and related Apicomplexan parasites play a major role in transmission success. Here, we address 2 fundamental issues in the sex ratios of the rodent malaria parasite, Plasmodium chabaudi.
West, SA, West, S A, Read, A F, REECE, S. E., West, S. A., Read, A. F., Duncan, A B, West, Stuart A, Reece, S E, Duncan, A., Reece, SE, Duncan, AB, Read, AF, Duncan, Alison B, Read, Andrew F   +14 more
core   +1 more source

Glutaredoxine reduzieren schnell Glutathionhydroper‐ und Glutathionpolysulfide

Angewandte Chemie, EarlyView.
Glutaredoxine (Grx) reduzieren Glutathionpolysulfide (GSSnSG) schnell zu Glutathionhydroper/polysulfiden (GSSnH) oder GSSnH zu Wasserstoff(poly)sulfiden (H2Sn). Die Reduktion glutathionylierter Grx durch reduziertes Glutathion (GSH) liefert Glutathiondisulfid (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

Spleen Infarction in Plasmodium Infection [PDF]

Liaquat National Journal of Primary Care
Dear Editor, Malaria is a zoonosis causing public health problems, and more than 600,000 deaths yearly mainly younger; splenic infarction or rupture are rarely described [1- 5].
Vitorino Modesto dos Santos, Andressa Plaça Tedeschi, Julia Campos Modesto   +2 more
doaj   +1 more source

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

eLife, 2020
The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle.
Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, Sean T Prigge   +7 more
doaj   +1 more source

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. [PDF]

, 2009
The malarial parasite Plasmodium falciparum possesses a functional thioredoxin and glutathione system comprising the dithiol-containing redox proteins thioredoxin (Trx) and glutaredoxin (Grx), as well as plasmoredoxin (Plrx), which is exclusively found ...
Sturm, Nicole, Becker Katja, Koncarevic, Sasa, Forchhammer, Karl, Mailu, Boniface M., Rahlfs, Stefan, Katja Becker, Deponte, Marcel, Koncarevic Sasa, Becker, Katja, Sturm Nicole, Mailu Boniface M., Marcel Deponte, Deponte Marcel, Jortzik, Esther, Stefan Rahlfs, Jortzik Esther, Esther Jortzik, Karl Forchhammer, Nicole Sturm, Forchhammer Karl, Boniface M Mailu, Sasa Koncarevic, Rahlfs Stefan   +23 more
core   +2 more sources

Glutaredoxins Rapidly Reduce Glutathione Hydroper‐ and Polysulfides

Angewandte Chemie International Edition, EarlyView.
Glutaredoxins (Grx) rapidly reduce glutathione polysulfides (GSSnSG) to glutathione hydroper/polysulfides (GSSnH) or GSSnH to hydrogen (poly)sulfides (H2Sn). Reduction of glutathionylated glutaredoxins by reduced glutathione (GSH) yields glutathione disulfide (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

eLife, 2018
Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery.
Nicole L Bertschi, Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K Gupta, Sam O Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W Faber, Erika L Flannery, Sebastian A Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T Diagana, Clemens HM Kocken, Guglielmo Roma   +23 more
doaj   +1 more source