Results 81 to 90 of about 322,747 (249)

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections [PDF]

, 2013
Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox Singh, Janet, Daneshvar, Cyrus, Davis, Timothy M. E., Divis, Paul C. S., Rafa'ee, Mohammad Z., Singh, Balbir, Zakaria, Siti K.   +6 more
core   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Physiological, environmental, and life-history drivers of haemosporidian infections in non-passerine birds from a rehabilitation center

Frontiers in Parasitology
IntroductionPathogens and parasites play a crucial role in shaping ecological and evolutionary processes, influencing the behavior, physiology, and survival of their hosts across diverse ecosystems.
Lis Marques de Carvalho e Vieira, Victor Aguiar de Souza Penha, Kevin J. McGraw, Amanda Vitória Dornelas da Silva, Erika Martins Braga   +4 more
doaj   +1 more source

Quantitative electroencephalographic measures during postmalarial epileptogenesis

Epilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi, Suzanna Mwanza, Hitten P. Zaveri, Joseph Kasolo, Angela Masempela, Thelma Musakanya, Tina Mwale, Violet Nambeye, Rosemary Nyriongo, Ruth A. Tembo, Christopher Cortina, Bo Zhang, Gretchen L. Birbeck, Alexander Rotenberg, Archana A. Patel   +14 more
wiley   +1 more source

Antimalarial potential of Kerala Ayurvedic Water “Pathimugam”

Journal of Vector Borne Diseases
Background & objectives: The persistent threat of drug resistant malaria demands new cures. Low prevalence of malaria in the Indian state of Kerala compared with other proximal states led us to explore if there is any traditional practice in Kerala which
Naveen Kumar Kaushik, Dinkar Sahal
doaj   +1 more source

Evaluation of the Anti-Malarial Activity of the Crude Root Extract and Solvent Fraction of Sesamum indicum (Fabaceae)

Journal of Experimental Pharmacology, 2023
Fentaw Girmaw, Getachew Ashagrie Department of Pharmacy, College of Health Science, Woldia University, Woldia, EthiopiaCorrespondence: Fentaw Girmaw, Department of Pharmacy, College of Medicine and Health Science, Woldia University, P.O. Box 400, Woldia,
Girmaw F, Ashagrie G
doaj  

Space-time variation of malaria incidence in Yunnan province, China [PDF]

, 2016
BACKGROUND Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria
Barnett, Adrian G, Cheng, Zhang, Clements, Archie C A, Snow, Robert W, Zhou, Hom   +4 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Acute disruption of bone marrow B lymphopoiesis and apoptosis of transitional and marginal zone B cells in the spleen following a blood-stage Plasmodium chabaudi infection in mice [PDF]

, 2011
B cells and antibodies are essential for the protective immune response against a blood-stagePlasmodiuminfection. Although extensive research has focused on memory as well as plasma B-cell responses during infection, little is known about how malaria ...
Bockstal, Viki, Geurts, Nathalie, Magez, Stefan   +2 more
core   +2 more sources