Results 91 to 100 of about 258,281 (284)

Plasmodium-helminth coinfection and its sources of heterogeneity across East Africa. [PDF]

, 2012
BACKGROUND: Plasmodium-helminth coinfection can have a number of consequences for infected hosts, yet our knowledge of the epidemiology of coinfection across multiple settings is limited.
Pullan, Rachel L, Pullan, RL, Kolaczinski, JH, Kolaczinski, Jan H, Snow, RW, Brooker, Simon J, Ashton, Ruth A, Snow, Robert, Kabatereine, NB, Kabatereine, Narcis B, Gitonga, Caroline W, Brooker, SJ, Snow, Robert W, Ashton, RA, Gitonga, CW   +14 more
core   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Role of climatic factors on the perennial malaria cases in Kalahandi district of Odisha, eastern India

Journal of Vector Borne Diseases
Background & objectives: Vector-borne diseases, particularly mosquito-bome illnesses, cause significant global health challenges, leading to approximately 700,000 deaths annually.
Subrat Kumar Panigrahi, Smruti Ranjan Parida, Dibyanee Mohanty, Punyatoya Panda, Manoj Kumar Meher, Priyanka Mohanty, Pruthiraj Mohapatra, Aishwarya B Acharya, Bijayalaxmi Sahu, Tapan Kumar Barik   +9 more
doaj   +1 more source

Evaluation of the Anti-Malarial Activity of the Crude Root Extract and Solvent Fraction of Sesamum indicum (Fabaceae)

Journal of Experimental Pharmacology, 2023
Fentaw Girmaw, Getachew Ashagrie Department of Pharmacy, College of Health Science, Woldia University, Woldia, EthiopiaCorrespondence: Fentaw Girmaw, Department of Pharmacy, College of Medicine and Health Science, Woldia University, P.O. Box 400, Woldia,
Girmaw F, Ashagrie G
doaj  

An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum [PDF]

, 2012
This report describes the optimization and evaluation of a simple single-step lysis protocol to measure luciferase bioluminescence from genetically modified Plasmodium falciparum.
Hasenkamp Sandra, Wong Eleanor H, Horrocks, Paul, Wong, EH, Eleanor H Wong, Wong, Eleanor H., Paul Horrocks, Wong, E.H., Horrocks Paul, Hasenkamp, S., Horrocks, P., Hasenkamp, Sandra, Hasenkamp, S, Horrocks, P, Sandra Hasenkamp, Horrocks   +15 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay. [PDF]

, 2011
The diversity in the Plasmodium falciparum genome can be used to explore parasite population dynamics, with practical applications to malaria control.
Abdoulaye Djimde, Newbold, CI, Steven M Kiara, MacInnis, B, Jiang Hongying, Amaratunga, Chanaki, Mangano Valentina, Panos Deloukas, Socheat, Duong, Kirk Rockett, Jiang, H, Kivinen, K, MacInnis Bronwyn, Borrmann Steffen, Kwiatkowski, DP, Kiara Steven M., Kwiatkowski, Dominic, Pascal Michon, Valentina Mangano, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Djimde Abdoulaye, Christopher I. Newbold, Borrmann, S, Deloukas, P, Rockett, K, Su, X-Z, Dominic P. Kwiatkowski, Nicholas J White, Imwong, Mallika, Ouedraogo, JB, Anderson, Timothy, Nicholas J. White, White Nicholas J., Zongo Issaka, Campino, S, Taane G. Clark, MacInnis, Bronwyn, Auburn Sarah, Clark, Taane G, Clark, TG, Newbold, Christopher, Nosten, François, Issaka Zongo, Nzila, A, Rockett Kirk, Gwilliam Rhian, Kevin Marsh, Djimde, Abdoulaye, Newbold, Christopher I, Xin-Zhuan Su, Kivinen, Katja, Amaratunga Chanaki, Rhian Gwilliam, Nosten François, Susana Campino, White, Nicholas J, Sarah Auburn, Fairhurst, Rick M, Michon, P, Nzila, Alexis, Gwilliam, Rhian, Mueller, Ivo, Siba, P, Doumbo Ogobara K., Ivo Mueller, Marsh, K, Zongo, Issaka, Chanaki Amaratunga, Timothy Anderson, Christopher I Newbold, Imwong Mallika, Jean-Bosco Ouedraogo, Clark Taane G., Alexis Nzila, Socheat Duong, Imwong, M, Anderson, T, Kiara, SM, White, NJ, Marsh, Kevin, Jean Bosco Ouedraogo, Fairhurst, RM, Steven M. Kiara, Michon, Pascal, Doumbo, Ogobara K, Deloukas, Panos, Marsh Kevin, Su, Xin-Zhuan, Djimde, A, Peter Siba, Siba, Peter, Mueller, I, Mallika Imwong, Ogobara K. Doumbo, Anderson Timothy, Hongying Jiang, White, Nicholas, Gwilliam, R, Katja Kivinen, Kiara, Steven M, Michon Pascal, Mangano, V, Siba Peter, Kivinen Katja, Zongo, I, Mueller Ivo, Campino Susana, Rick M. Fairhurst, Amaratunga, C, Newbold Christopher I., Auburn, Sarah, Xin Zhuan Su, Auburn, S, Rockett, Kirk, Bronwyn Macinnis, Nzila Alexis, Duong Socheat, François Nosten, Nosten, F, Su, XZ, Ouedraogo Jean-Bosco, Ouedraogo, J-B, Ogobara K Doumbo, Campino, Susana, Socheat, D, Jiang, Hongying, Doumbo, OK, Su Xin-Zhuan, Mangano, Valentina, Rick M Fairhurst, Ouedraogo, Jean-Bosco, Fairhurst Rick M., Borrmann, Steffen, Steffen Borrmann, Deloukas Panos, Kwiatkowski, Dominic P   +137 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase. [PDF]

, 2012
Signalling by 3'-5'-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of the ...
Baker, David A, Lev Solyakov (122244), Solyakov, Lev, David A Baker, Flueck, Christian, Lev Solyakov, L. Solyakov (7638338), Hopp Christine S., Flueck Christian, Andrew Tobin (122248), David A. Baker (122252), Christine S Hopp, David A. Baker, D. A. Baker (7638335), A. B. Tobin (7638326), Solyakov Lev, C. Flueck (7638332), Andrew Tobin, Christine S. Hopp (122239), Baker David A., Tobin Andrew, Christian Flueck, C. S. Hopp (7638329), Tobin, Andrew, Christian Flueck (122240), Hopp, Christine S   +25 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source