Results 91 to 100 of about 322,747 (249)

Solar Geoengineering Effects on Malaria Transmission Risk in South Asia Under G6sulfur Scenario

International Journal of Climatology, EarlyView.
Comparison of EIR (unit: No of infected bites per person per day) for each considered country in South Asia, under the considered scenarios, averaged over the period 2020–2090. A regression equation is shown for each country (for Bhutan EIRG = 0.1690 × 10−10 EIRS + 0.5968 × 10−12) to illustrate the projected trend.
Athar Hussain, Muhammad Ali Khan, Muhammad Shoaib   +2 more
wiley   +1 more source

PNAS plus: plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state [PDF]

, 2012
The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids. Its amino acid needs are met largely through the degradation of host erythrocyte hemoglobin; however the parasite must acquire isoleucine exogenously, because this ...
Baertl, Bozdech, Brennand, C. Doerig, C. Fennell, Callebaut, Codd, D. E. Goldberg, Daily, Dever, Divo, Dyer, E. S. Istvan, Fennell, Fidock, Francis, Functional Genomics Workshop Group, Harris, Hinnebusch, Hinnebusch, Kafsack, Kilberg, Kim, Kourtis, L. Altenhofen, Lambros, Llinas, Lu, Lu, M. Llinas, Olszewski, Payne, Pfaller, Roth, Russo, S. A. Cobbold, S. E. Babbitt, Sharma, Sherman, Sims, Soeters, Towbin, Trager, van Werven, Wek, Zaborske, Zolg   +46 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

eLife, 2019
The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts.
Daniel M Parker, Sai Thein Than Tun, Lisa J White, Ladda Kajeechiwa, May Myo Thwin, Jordi Landier, Victor Chaumeau, Vincent Corbel, Arjen M Dondorp, Lorenz von Seidlein, Nicholas J White, Richard J Maude, François Nosten   +12 more
doaj   +1 more source

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]

, 2002
Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Docampo, Flohe, Moreno, Viode, Henderson, Walsh, Krauth-Seigel, Muller, Nogoceke, Tetaud, Wilkinson, Wilkinson, Tetaud, Wilkinson, Boveris, Fairlamb, Mehlotra, Carnieri, Kendall, Kelly, Gibson, Martinez-Calvillo, Kelly, Kelly, Kelly, Cannata, Rutter, Easterby, Gommel, Steinert, Sommer, Opperdoes, Opperdoes, Michels, Parsons, Blattner, Bjornstedt, Sztajer, Horiguchi, Holgren, Fabianek, Shih, Shih, van den Bosch, Subramani, Keller, Singh, Singh, Boveris, Duffieux, Goodman, Knoops, Yamashita, Verdoucq, Seo, Lopez, Krieger   +56 more
core   +3 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

The Sporozoite's Journey Through the Mosquito: A Critical Examination of Host and Parasite Factors Required for Salivary Gland Invasion

Frontiers in Ecology and Evolution, 2019
Although much progress has been made in the fight against malaria, the number of people that contract this disease due to the bite of an Anopheline mosquito remains unacceptably high.
Bianca B. Kojin, Zach N. Adelman
doaj   +1 more source

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

, 2009
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew, Gosling, Roly, Gesase, Samwel, Mosha, Jacklin, Greenwood, Brian, Chandramohan, Daniel   +5 more
core   +1 more source