Results 151 to 160 of about 192,328 (309)
Certain amplified genomic-DNA fragments (AGFs) may be involved in cell cycle progression and chloroquine is found to induce the production of cell-cycle-associated AGFs (CAGFs) in Plasmodium falciparum [PDF]
arXiv, 2015 It is well known that cyclins are a family of proteins that control cell-cycle progression by activating cyclin-dependent kinase. Based on our experimental results, we propose here a novel hypothesis that certain amplified genomic-DNA fragments (AGFs) may also be required for the cell cycle progression of eukaryotic cells and thus can be named as cell ...
arxiv
Journal of Infectious Diseases, 2015 BACKGROUND The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in
Shannon Takala-Harrison +44 more
semanticscholar +1 more source
Cytotoxic Signature and IFN‐γ Production Dominate CD4+ T‐Cell Response During Human Toxoplasmosis
Immunology, EarlyView.Overview of CD4+ T‐cell subsets in patients with toxoplasmosis. Schematic drawing summarising the most important alterations in CD4+ T‐cell subsets, illustrated in different colours, from patients in distinct stages of toxoplasmosis, represented with different colours, with (lesion) or without (no lesion) ocular manifestations.
Priscilla Miranda Henriques +14 more
wiley +1 more source
Mosquito Vectors and the Globalization of Plasmodium falciparum Malaria.
Annual Review of Genetics, 2016 Plasmodium falciparum malaria remains a devastating public health problem. Recent discoveries have shed light on the origin and evolution of Plasmodium parasites and their interactions with their vertebrate and mosquito hosts. P.
Alvaro Molina-Cruz +4 more
semanticscholar +1 more source
Plasmodium falciparum picks (on) EPCR
Blood, 2014 AbstractOf all the outcomes of Plasmodium falciparum infection, the coma of cerebral malaria (CM) is particularly deadly. Malariologists have long wondered how some patients develop this organ-specific syndrome. Data from two recent publications support a novel mechanism of CM pathogenesis in which infected erythrocytes (IEs) express specific virulence
William C. Aird +2 more
openaire +4 more sources
A Bayesian approach to inferring the phylogenetic structure of communities from metagenomic data [PDF]
arXiv, 2013 Metagenomics provides a powerful new tool set for investigating evolutionary interactions with the environment. However, an absence of model-based statistical methods means that researchers are often not able to make full use of this complex information.
arxiv
PLoS Medicine, 2015 Background Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods ...
Natalie E Hofmann +5 more
semanticscholar +1 more source
Imaging malaria parasites across scales and time
Journal of Microscopy, EarlyView.Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley +1 more source
Mild Depression of Platelet Count and Altered Platelet Function in Acute Plasmodium Falciparum Infection [PDF]
, 1977 E.M. Essien, M.I. Ebhota
openalex +1 more source
Molecular Microbiology, EarlyView.Biochemical data on the isolated Na+/H+‐exchanging ATPase, PfATP4, from the malaria parasite are missing. Here, we expressed and purified the nucleotide and phosphate binding domains as a soluble protein and identified key residues by enzymatic characterization of generated point mutants.
Timo Beyer +3 more
wiley +1 more source