Results 141 to 150 of about 113,438 (254)

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, Volume 81, Issue 6, Page 2036-2046, June 2026.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia

, 2006
The Plasmodium falciparum variant erythrocyte surface antigens known as PfEMP1, encoded by the var gene family, are thought to play a crucial role in malaria pathogenesis because they mediate adhesion to host cells and immuno-modulation.
Thera, Mahamadou A, Stone, Graham N, Koné, Abdoulaye K, Challis, Richard J, Lyke, Kirsten E, Rowe, J Alexandra; id_orcid, Kyriacou, Helen M, Raza, Ahmed, Doumbo, Ogobara K, Plowe, Christopher V   +9 more
core   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

, 2001
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 ...
David R. Cavanagh, Cavanagh, D R, Cavanagh, DR, Ibrahim M. Elhassan, Elhassan, I M, Jana S. McBride, Theander, TG, Kevin Marsh, McBride, JS, Elhassan, A, Hviid, L, Khalil, E A T G, Ahmed Elhassan, Thor G. Theander, Cavanagh, David, Arnot, DE, Marsh, K, David E. Arnot, E. At Tahir G. Khalil, Khalil, EA, McBride, J S, Arnot, D E, Elhassan, IM, Theander, T G, Marsh, Kevin, Lars Hviid, Dobano, C, Carlota Dobaño, Khalil, E A   +28 more
core   +1 more source

Beyond Temperature: Relative Humidity Systematically Shifts Juvenile Thermal Performance and Projected Population Growth in a Malaria Vector

Ecology Letters, Volume 29, Issue 6, June 2026.
Understanding how ectotherms respond to environmental change requires accounting for multiple interacting climatic factors; yet relative humidity is rarely integrated with temperature in trait‐based performance frameworks. Using laboratory experiments and an analytic population growth model, we show that humidity systematically modifies juvenile life ...
Paul J. Huxley, Joel J. Brown, Brandyce St. Laurent, Britny Johnson, Olivia Y. Cheung, Anna Asamoah, Brandon D. Hollingsworth, Eric R. Bump, Michael C. Wimberly, Mercedes Pascual, Leah R. Johnson, Courtney C. Murdock   +11 more
wiley   +1 more source

Malària durant l'embaràs: immunitat materna i expressió de gens implicats en la citoadhesió de "Plasmodium falciparum" [PDF]

, 2011
[cat] El risc d’infecció per Plasmodium falciparum, el paràsit causant de la malària, augmenta durant l’embaràs. La disminució del risc d’infecció en embarassos successius s’atribueix a l’adquisició d’anticossos contra eritròcits infectats a la placenta,
Rovira Vallbona, Eduard
core  

Genotyping of C and F Regions of Plasmodium Falciparum EBA-175 in South-East of Iran

Medical Laboratory Journal, 2014
Background and Objective: The Plasmodium falciparum EBA-175, via Sialic acid dependent glycophorin A, binds to red blood cells and thus plays a critical role in cell invasion. Some part of second allele in its gene encoding in FCR-3 (Section F) and CAMP (
A Jamshidi, M Mousavi Ghahfarrokhi, A Gharaei, A Ebrahimzadeh, M Jaffari Modrek, A Ansari Moghadam, S Mohammadi   +6 more
doaj  

Improved synchronous production of Plasmodium falciparum gametocytes in vitro.

, 2007
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P.
Sutherland, Colin J, Baker, David A, Sharp, Sarah, Taylor, Cathy J, McRobert, Louisa, Fivelman, Quinton L, Swales, Claire A, Saeed, Maha   +7 more
core   +1 more source

Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania

Parasites & Vectors
Background Recent studies point to the need to incorporate the detection of non-falciparum species into malaria surveillance activities in sub-Saharan Africa, where 95% of the world’s malaria cases occur.
Zachary R. Popkin-Hall, Misago D. Seth, Rashid A. Madebe, Rule Budodo, Catherine Bakari, Filbert Francis, Dativa Pereus, David J. Giesbrecht, Celine I. Mandara, Daniel Mbwambo, Sijenunu Aaron, Abdallah Lusasi, Samwel Lazaro, Jeffrey A. Bailey, Jonathan J. Juliano, Julie R. Gutman, Deus S. Ishengoma   +16 more
doaj   +1 more source

Comprehensive analysis of molecular markers linked to antimalarial drug resistance in Plasmodium falciparum in Northern, Northeastern and Eastern Uganda

Malaria Journal
Background In Uganda, antimalarial resistance in Plasmodium falciparum poses serious public health and treatment challenges. Globally, recent data have highlighted the roles of following genes in malaria resistance: Plasmodium falciparum dihydrofolate ...
Peter Olupot-Olupot, George Paasi, Thomas Katairo, Jimmy Patrick Alunyo, Alice Nakiyemba, Gilbert Gilibrays Ocen, Stephen Pande, Florance Alaroker, William Okiror, Emmaluel Ocen, Alex Oula, Charles Benard Okalebo, Ongodia Paul, Denis Amorut, Stephen Tukwasibwe, Susan Nabadda Ndidde, Isaac Sewanyana, Samuel L. Nsobya   +17 more
doaj   +1 more source