Results 1 to 10 of about 66,832 (203)

The genetic landscape of origins of replication in P. falciparum. [PDF]

Nucleic Acids Res, 2023
Abstract Various origin mapping approaches have enabled genome-wide identification of origins of replication (ORI) in model organisms, but only a few studies have focused on divergent organisms. By employing three complementary approaches we provide a high-resolution map of ORIs in Plasmodium falciparum, the deadliest human malaria ...
Castellano CM, Lacroix L, Mathis E, Prorok P, Hennion M, Lopez-Rubio JJ, Méchali M, Gomes AR.   +7 more
europepmc   +4 more sources

P. falciparum Invasion and Erythrocyte Aging. [PDF]

Cells
Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose receptors for the pathogen ligands and, on the other hand, maintain the right geometry to facilitate merozoite attachment and entry into the red blood cell. Both characteristics change with the maturation of erythrocytes. Some Plasmodia prefer younger vs.
Alves-Rosa MF, Tayler NM, Dorta D, Coronado LM, Spadafora C.   +4 more
europepmc   +4 more sources

Plasmodium vivax in the Era of the Shrinking P. falciparum Map

Trends in Parasitology, 2020
Plasmodium vivax es una causa importante de malaria, asociada con una importante carga de salud pública. Si bien las actividades mejoradas de control de la malaria han reducido con éxito la incidencia de la malaria por Plasmodium falciparum en muchas áreas, ha habido un aumento constante en la proporción de malaria debido a P.
Kamala Thriemer, Robert Commons, Kamini Mendis   +2 more
exaly   +3 more sources

Functional prediction of human erythrocytic miR-451a on Plasmodium falciparum 3D7 transcriptome—an in-silico study [PDF]

ExRNA, 2021
Background: Plasmodium falciparum (P. falciparum) is one of the deadliest species responsible for the major deaths related to malaria. Recently emerging research has focused on small noncoding RNAs especially mature microRNAs (miRNAs) (19-25 nts) which ...
Urja Joshi, Maulik Patel, Himanshu Pandya, Linz Buoy George, Hyacinth Highland   +4 more
doaj   +1 more source

Compensating P. falciparum artemisinin resistance [PDF]

Cell Host & Microbe, 2021
Amino acid deprivation from reduced hemoglobin degradation in Pfkelch13 artemisinin-resistant parasites reduces fitness. In this issue of Cell Host & Microbe, Mesén-Ramírez et al. decipher the role of nutrient permeable channel activity within the parasitophorous vacuolar membrane to compensate for this fitness cost in asexual blood-stage Plasmodium ...
Platon, Lucien, Cao, Jun, Menard, Didier
openaire   +3 more sources

Performance and accuracy of SD Bioline malaria Ag P.f (05fk50) in relation to microscopy as the gold standard technique for malaria diagnosis [PDF]

Cellular, Molecular and Biomedical Reports, 2023
Successful malaria diagnosis is the mainstay of successful treatment, prevention and eradication of malaria infection. Apart from the gold standard technique (Microscopy), numerous diagnostic techniques perform a similar function to microscopy and in ...
Ismail Muhammad, Pukuma Sale, Tanko Muhammad, Ali Rufai, Augustine Midala, Bala Abubakar   +5 more
doaj   +1 more source

Controlling drug resistance by targeting Plasmodium falciparum heat shock protein 70-1, a chaperone at the centre of protein quality control mechanism: a review

All Life, 2023
The survival of the malaria parasite is highly dependent on withstanding physiological stresses, which are a proportional response to parasite invasion within the hostile human host environment.
Douglas A. M. Ruhwaya, Brilliant Nyathi, Gadzikano Munyuki, Ryman Shoko, Grace Mugumbate   +4 more
doaj   +1 more source

Thrombocytopenia in malaria and its diagnostic significance: A prospective study

Journal of Clinical and Scientific Research, 2023
Background: Thrombocytopenia is a common finding in malaria. Although a reliable diagnostic marker, prognostic implications could vary in the types of malaria.
Prudhivi Krishna, Manoj Kumar Chalamalasetty   +1 more
doaj   +1 more source

Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores [PDF]

Journal of the Serbian Chemical Society, 2008
Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds.
Opsenica Igor M., Smith Kirsten K., Gerena Lucia, Gaica Sandra, Šolaja Bogdan A.   +4 more
doaj   +1 more source

Validation of micro-chip based PCR assays for diagnosis of both Plasmodium falciparum and Plasmodium vivax

Journal of Vector Borne Diseases, 2022
Background & objectives: Microscopy is considered as the gold standard for malaria diagnosis, however sub-microscopic infections can only be detected by Polymerase chain reaction, which demands high cost and elaborate laboratory setup. The Micro-chip PCR
Syed Shah Areeb Hussian, Vijay P Ojha, Meenakshi Jeena, Manju Rahi, Anupkumar Anvikar, Amit Sharma, Ramesh C Dhiman   +6 more
doaj   +1 more source