Results 121 to 130 of about 113,438 (254)

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. [PDF]

, 2009
BACKGROUND: The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to transition, as intervention ...
Abdullah Al-Taiar, Idro, Richard, Okiro Emelda A, Berkley, James, Al-Taiar Abdullah, Berkley James A, Berkley, James A, Snow, Robert, Al-Taiar, Abdullah, Berkley, JA, Emelda A Okiro, Okiro, EA, James A Berkley, Snow, Robert W, Okiro, Emelda A, Idro, R, Snow, RW, Robert W Snow, Snow Robert W, Reyburn, H, Hugh Reyburn, Richard Idro, Reyburn Hugh, Al-Taiar, A, Reyburn, Hugh, Idro Richard   +25 more
core   +1 more source

Evaluation of the rapid diagnostic test SDFK40 (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a non-endemic setting

Malaria Journal, 2011
Background The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting ...
Van Esbroeck Marjan, Bottieau Emmanuel, Cnops Lieselotte, Gillet Philippe, Maltha Jessica, Bruggeman Cathrien, Jacobs Jan   +6 more
doaj   +1 more source

Effect of Home‐Based Multiple Micronutrient Powder Fortification on Haemoglobin Levels in Infants in Nampula, Mozambique: A Pragmatic Clinical Trial

Maternal &Child Nutrition, Volume 22, Issue 3, July 2026.
ABSTRACT To conduct a pragmatic clinical trial with multiple micronutrient powders (MNPs) for anaemia prevention during the first year of life in primary care in Nampula, Mozambique. A total of 275 infants, aged 6–8 months, were randomly assigned to intervention (IG, n = 145) and control (CG, n = 130) groups. The IG received 90 sachets of MNP for daily
Ana Raquel Ernesto Manuel Gotine, Marly Augusto Cardoso   +1 more
wiley   +1 more source

Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria. [PDF]

, 2009
BACKGROUND: Studies to identify phenotypically-associated polymorphisms in the Plasmodium falciparum 23 Mb genome will require a dense array of marker loci.
David J Conway, Conway, David J, Chokejindachai, Watcharee, Watcharee Chokejindachai   +3 more
core   +1 more source

Molecular Detection of Malaria in South Punjab with Higher Proportion of Mixed Infections

Iranian Journal of Parasitology, 2014
Background: Malaria is well known for its fatalities worldwide, Plasmodium vivax and the Plasmodium falciparum are the two important species of malaria reported from Pakistan and creating lots of morbidities across the country.
Saba Shahzadi, Tanveer Akhtar, Atif Hanif, Sumrin Sahar, Sadaf Niaz, Hazrat Bilal   +5 more
doaj  

Synthesis, Characterization, and Anti‐Plasmodium falciparum Activity of a New Copper(II) Complex Containing 2‐(Tert‐Butoxy)‐6‐(1H‐imidazol‐1‐yl)pyridine

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
The graphical abstract illustrates the formation of a Cu(II) complex from azole‐based ligand, highlighting metal–ligand synergy. The resulting coordination compound acts as a bioactive entity against Plasmodium, where metal coordination enhances antiparasitic activity, outperforming the free ligand and demonstrating its potential as an antimalarial ...
Alexander Patiño‐Cubides, María Camila Velasco‐Pareja, Mario A. Macías, María F. Yasnot‐Acosta, Ana Rodriguez, Augusto Valderrama‐Aguirre, John J. Hurtado   +6 more
wiley   +1 more source

Evidence of Plasmodium vivax circulation in western and eastern regions of Senegal: implications for malaria control

Malaria Journal
Background Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently Plasmodium vivax have also been ...
Aida S. Badiane, Bassirou Ngom, Tolla Ndiaye, Deirdre Cunningham, James Campbell, Amy Gaye, Aita Sène, Mouhamad Sy, Daouda Ndiaye, Davis Nwakanma, Jean Langhorne   +10 more
doaj   +1 more source

Sero-identification of the aetiologies of human malaria exposure (Plasmodium spp.) in the Limu Kossa District of Jimma Zone, South western Ethiopia

Malaria Journal, 2019
Background Malaria remains a very important public health problem in Ethiopia. Currently, only Plasmodium falciparum and Plasmodium vivax are considered in the malaria diagnostic and treatment policies. However, the existence and prevalence of Plasmodium
Sindew Mekasha Feleke, Bokretsion Gidey Brhane, Hassen Mamo, Ashenafi Assefa, Adugna Woyessa, Guilherme Maerschner Ogawa, Vitaliano Cama   +6 more
doaj   +1 more source

Total Synthesis and Antimalarial Studies of Caelestines A–C

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Total synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Henry S. T. Smith, Aaron M. Lock, Vicky M. Avery, Rohan A. Davis   +3 more
wiley   +1 more source