Analysis of pir gene expression across the Plasmodium life cycle [PDF]
Malaria Journal, 2021 Background Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immune evasion ...
Timothy S. Little +11 more
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A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle. [PDF]
PLoS ONE, 2010 The human malaria parasite Plasmodium falciparum is responsible for the majority of malaria-related deaths. Tools allowing the study of the basic biology of P.
Arthur M Talman +2 more
doaj +7 more sources
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle
Cell Reports, 2015 New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials.
Hangjun Ke +9 more
doaj +7 more sources
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
PLoS Computational Biology, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
David F Read +4 more
doaj +3 more sources
Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research [PDF]
Frontiers in Microbiology, 2015 The unicellular protozoan parasites of the genus Plasmodium impose on human health worldwide the enormous burden of malaria. The possibility to genetically modify several species of malaria parasites represented a major advance in the possibility to ...
Giulia eSiciliano, Pietro eAlano
doaj +5 more sources
Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle. [PDF]
PLoS Pathogens, 2010 The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a
Balbir K Chaal +4 more
doaj +3 more sources
Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host. [PDF]
PLoS ONE, 2017 Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP).
Konstantinos Koussis +6 more
doaj +3 more sources
A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. [PDF]
Cell Host Microbe, 2017 Modrzynska K +10 more
europepmc +2 more sources
Same, same but different: Exploring Plasmodium cell division during liver stage development
PLoS Pathogens, 2023 Plasmodium parasites have a complex life cycle alternating between a mosquito and a vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication ...
Magali Roques +3 more
doaj +2 more sources
Microorganisms, 2023 Malaria, caused by Plasmodium protozoal parasites, remains a leading cause of morbidity and mortality. The Plasmodium parasite has a complex life cycle, with asexual and sexual forms in humans and Anopheles mosquitoes.
Masafumi Yoshinaga +6 more
doaj +1 more source