Results 21 to 30 of about 68,345 (214)

Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?

Frontiers in Cellular and Infection Microbiology, 2021
Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado, Marta Machado, Salome Steinke, Markus Ganter   +3 more
doaj   +1 more source

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

eLife, 2020
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins ...
Aurélia C Balestra, Mohammad Zeeshan, Edward Rea, Carla Pasquarello, Lorenzo Brusini, Tobias Mourier, Amit Kumar Subudhi, Natacha Klages, Patrizia Arboit, Rajan Pandey, Declan Brady, Sue Vaughan, Anthony A Holder, Arnab Pain, David JP Ferguson, Alexandre Hainard, Rita Tewari, Mathieu Brochet   +17 more
doaj   +1 more source

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice [PDF]

Nature Communications, 2015
AbstractExperimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo. Here we improve on previous protocols to achieve efficient double engraftment of TK-NOG mice by human primary hepatocytes ...
Soulard, Valérie, Bosson-Vanga, Henriette, Lorthiois, Audrey, Roucher, Clémentine, Franetich, Jean-François, Zanghi, Gigliola, Bordessoulles, Mallaury, Tefit, Maurel, Thellier, Marc, Morosan, Serban, Le Naour, Gilles, Capron, Frédérique, Suemizu, Hiroshi, Snounou, Georges, Moreno-Sabater, Alicia, Mazier, Dominique   +15 more
openaire   +3 more sources

Checks and balances? DNA replication and the cell cycle in Plasmodium

Parasites & Vectors, 2018
It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease.
Holly Matthews, Craig W. Duffy, Catherine J. Merrick   +2 more
doaj   +1 more source

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

mBio, 2021
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with an infectious blood meal, representing a critical stage for parasite transmission.
Sudhir Kumar, Meseret T. Haile, Michael R. Hoopmann, Linh T. Tran, Samantha A. Michaels, Seamus R. Morrone, Kayode K. Ojo, Laura M. Reynolds, Ulrike Kusebauch, Ashley M. Vaughan, Robert L. Moritz, Stefan H. I. Kappe, Kristian E. Swearingen   +12 more
doaj   +1 more source

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission [PDF]

, 2020
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Abel, Steven, Batugedara, Gayani, Bottrill, Andrew R., Boucher, Matthew, Brady, Declan, Daniel, Emilie, Freville, Aline, Gupta, Dinesh, Holder, Anthony A., Hollin, Thomas, Le Roch, Karine G., Lu, Xueqing Maggie, Pandey, Rajan, Rea, Edward, Stanway, Rebecca R., Tewari, Rita, Wall, Richard J., Wheatley, Sally, Zeeshan, Mohammad   +18 more
core   +3 more sources

Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP [PDF]

, 2005
Plasmodium falciparum, the causative agent of malaria, relies on a sophisticated protein secretion system for host cell invasion and transformation.
Cowman, Alan F., de Souza Dias, Suzana, Gilberger, Tim W., Langer, Christine, Marti, Matthias, Pearce, J. Andrew, Struck, Nicole S.   +6 more
core   +1 more source

A proteomic view of the Plasmodium falciparum life cycle

Nature, 2002
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
Florens, L, Washburn, M, Raine, J, Anthony, R, Grainger, M, Haynes, J, Moch, J, Muster, N, Sacci, J, Tabb, D, Witney, A, Wolters, D, Wu, Y, Gardner, M, Holder, A, Sinden, R, Yates, JR, Carucci, D   +17 more
openaire   +2 more sources

Copper-transporting ATPase is important for malaria parasite fertility [PDF]

, 2013
Homeostasis of the trace element copper is essential to all eukaryotic life. Copper serves as a cofactor in metalloenzymes and catalyses electron transfer reactions as well as the generation of potentially toxic reactive oxygen species. Here, we describe
Kenthirapalan, Sanketha, Kooij, Taco W. A., Matuschewski, Kai, Waters, Andrew P.   +3 more
core   +2 more sources

Evolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites

Nature Communications, 2023
Within-host survival and between-host transmission are key life-history traits of single-celled malaria parasites. Understanding the evolutionary forces that shape these traits is crucial to predict malaria epidemiology, drug resistance, and virulence ...
Paola Carrillo-Bustamante, Giulia Costa, Lena Lampe, Elena A. Levashina   +3 more
doaj   +1 more source