Malaria Diagnosis and the Plasmodium Life Cycle: the BFO Perspective [PDF]
Nature Precedings, 2009 Definitive diagnosis of malaria requires the demonstration through laboratory tests of the presence within the patient of malaria parasites or their components.
Barry Smith, Werner Ceusters
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Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes. [PDF]
PLoS ONE, 2013 Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully ...
Hui Shi +7 more
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Variation in selective constraints along the Plasmodium life cycle. [PDF]
Infect Genet Evol, 2021 Plasmodium parasites, the cause of malaria, have a complex life cycle, infecting alternatively vertebrate hosts and female Anopheles mosquitoes and undergoing intra- and extra-cellular development in several organs of these hosts. Most of the ~5000 protein-coding genes present in Plasmodium genomes are only expressed at specific life stages, and ...
Tebben K, Bradwell K, Serre D.
europepmc +3 more sources
Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle. [PDF]
Antimicrob Agents Chemother, 2015 ABSTRACT Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against Plasmodium asexual blood stages to be developed for treatment.
Erath J +9 more
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Targeting Plasmodium Life Cycle with Novel Parasite Ligands as Vaccine Antigens. [PDF]
Vaccines (Basel)The WHO reported an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. A total of 94% of malaria deaths occurred in Africa, 80% of which were children under 5. In other words, one child dies every minute from malaria. The RTS,S/AS01 malaria vaccine, which uses the Plasmodium falciparum circumsporozoite protein (CSP)
Khan S, Patel MP, Patni AD, Cha SJ.
europepmc +4 more sources
Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)
Frontiers in Molecular Biosciences, 2021 Plasmodium falciparum is a causative agent for malaria and has a complex life cycle in human and mosquito hosts. During its life cycle, the malarial parasite Plasmodium goes through different asexual and sexual stages, in humans and mosquitoes ...
Jatin Behari +12 more
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The role of cGMP signalling in regulating life cycle progression of Plasmodium [PDF]
Microbes and Infection, 2012 The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and ...
Hopp, Christine S +2 more
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An epithelial serine protease, AgESP, is required for Plasmodium invasion in the mosquito Anopheles gambiae. [PDF]
PLoS ONE, 2012 Plasmodium parasites need to cross the midgut and salivary gland epithelia to complete their life cycle in the mosquito. However, our understanding of the molecular mechanism and the mosquito genes that participate in this process is still very limited ...
Janneth Rodrigues +6 more
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Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites
mBio, 2021 During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts.
Emily S. Mathews +2 more
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Activation of the hypnozoite: a part of Plasmodium vivax life cycle and survival [PDF]
Malaria Journal, 2011 Plasmodium vivax is the most widespread malaria parasite. It has a dormant stage in the human liver, which makes it difficult to eradicate. It is proposed that a relapse of vivax malaria, besides being genetically determined by the specific strain, is induced by the bites of uninfected vectors.The dormant stage maximizes the possibility for the ...
Huldén Larry, Hulden Lena
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