Results 201 to 210 of about 530,210 (299)

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, Volume 20, Issue 18, September 25, 2025.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Additional file 1 of Activity of Plasmodium vivax promoter elements in Plasmodium knowlesi, and a centromere-containing plasmid that expresses NanoLuc throughout the parasite life cycle

, 2021
Roberto R. Moraes Barros, Kittisak Thawnashom, Tyler J. Gibson, Jennifer S. Armistead, Ramoncito L. Caleon, Miho Kaneko, Whitney A. Kite, J. Patrick Mershon, Jacqueline Brockhurst, Theresa Engels, Lynn Lambert, Sachy Orr-Gonzalez, John H. Adams, Juliana M. Sá, Osamu Kaneko, Thomas E. Wellems   +15 more
openalex   +2 more sources

Resonance Raman Spectroscopic Study of the Unusual [4Fe‐4S]2+ Cluster of IspH, the Last Enzyme of the Methylerythritol Phosphate Pathway for Terpenoid Biosynthesis

ChemBioChem, Volume 26, Issue 18, September 18, 2025.
Raman spectroscopy confirms that the apical Fe atom of the [4Fe‐4S]2+ cluster of IspH is linked to H2O molecules and that the (E)‐4‐hydroxy‐3‐methyl‐but‐2‐en‐1‐yl diphosphate substrate and the propargyl diphosphate inhibitor lead to a change of coordination geometry. The loss of octahedral coordination of the apical Fe atom is also very likely when the
Hannah Jobelius, Philippe Chaignon, Gabriella I. Bianchino, Joanna Wandzik, Petra Hellwig, Myriam Seemann, Frederic Melin   +6 more
wiley   +1 more source

Additional file 6 of Analysis of pir gene expression across the Plasmodium life cycle

, 2021
Timothy S. Little, Deirdre Cunningham, Audrey Vandomme, Carlos Talavera‐López, Sarah Amis, Christopher Alder, John Addy, Sarah McLaughlin, Caroline Hosking, George K. Christophides, Adam J. Reid, Jean Langhorne   +11 more
openalex   +2 more sources

Targeting Mitochondrial Function in <i>Plasmodium falciparum</i>: Insight into Antimalarial Drugs and the Emerging Role of <i>Saccharomyces cerevisiae</i> as a Model System. [PDF]

Int J Mol Sci
Greco S, Assalve G, Lunetti P, Kayentao K, Dara A, Scaramuzzi D, Zara V, Ferramosca A.   +7 more
europepmc   +1 more source

Controlled human malaria infection studies: insights into recent advances and key immunological and ethical implementation lessons. [PDF]

Front Immunol
Ogwang R, Adan M, Bejon P, Kapulu MC.
europepmc   +1 more source

Imported Malaria and Congenital Acquisition in Infant, Portugal, 2024. [PDF]

Emerg Infect Dis
Lopes I, Dias J, Das Neves E, Morais M, Santos-Reis A, Garcia AM, Varandas L, Lopes D.   +7 more
europepmc   +1 more source

Emerging Molecular Mechanisms in Malaria Pathogenesis and Novel Therapeutic Approaches: A Focus on <i>P. falciparum</i> Malaria. [PDF]

Biomolecules
Sanyaolu A, Marinkovic A, Prakash S, Balendra V, Shazley O, Gardellini T, Jan A, Younis K, Okorie C, Izurieta R.   +9 more
europepmc   +1 more source

Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Cochicho Leonardo M, Albino SL, de Araújo WJS, Nascimento MVB, Rodríguez-Macías JD, Brazon EAM, Moura RO, Nogueira F, Nascimento IJDS.   +8 more
europepmc   +1 more source

Eratum to “A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle”

, 2004
Blandine Franke–Fayard, Holly E. Trueman, Jai Ramesar, Jacqui Mendoza, Maarten van der Keur, Reinier van der Linden, Robert E. Sinden, Andrew P. Waters, Chris J. Janse   +8 more
openalex   +1 more source