Results 51 to 60 of about 1,960,468 (279)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Ellipticity loss analysis for tangent moduli deduced from a large strain elastic–plastic self-consistent model [PDF]

, 2009
In order to investigate the impact of microstructures and deformation mechanisms on the ductility of materials, the criterion first proposed by Rice is applied to elastic–plastic tangent moduli derived from a large strain micromechanical model combined ...
LORRAIN, Jean-Paul, LEMOINE, Xavier, BERVEILLER, Marcel, ABED-MERAIM, Farid, FRANZ, Gérald, BEN ZINEB, Tarak   +5 more
core   +1 more source

Limit load based evaluation of plastic ? factor for C(T) specimen with a mismatched weld

Fracture and Structural Integrity, 2019
Plastic ? factor is adopted to account for crack tip plasticity while evaluating the fracture toughness of the materials as per ASTM E1820. It is valid only for homogeneous materials. The plastic ?
R. Nikhil, S.A. Krishnan, G. Sasikala, A. Moitra   +3 more
doaj   +1 more source

Reaching the Yield Point of a Glass During X-Ray Irradiation

Physical Review X, 2023
A solid loaded beyond the yield stress loses its elastic properties and becomes plastic. From a microscopic point of view, this limit corresponds to the condition where plastic regions become so densely packed that they give rise to system-spanning ...
Alessandro Martinelli, Federico Caporaletti, Francesco Dallari, Michael Sprung, Fabian Westermeier, Giacomo Baldi, Giulio Monaco   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Thermal effect of plastic dissipation at the crack tip on the stress intensity factor under cyclic loading [PDF]

, 2011
The authors acknowledge Arts et Métiers ParisTech and Fondation Arts et Métiers for the financial support of Paul C. Paris’ stay at LAMEFIP in 2009. The encouragement of Prof. Ivan Iordanoff, Director of LAMEFIP, is acknowledged with thanks.
PARIS, Paul C., T. Palin-Luc, PARIS, Paul Croce, PALIN-LUC, Thierry, RANC, Nicolas, P.C. Paris, PALIN LUC, Thierry, N. Ranc, Paris, Paul   +8 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The Unified Strength Theory for Plastic Limit Load Analysis of Vertical Shaft Lining

Advances in Civil Engineering, 2018
Plastic limit analysis is a significant application for structural design and failure prediction, implying that the potential bearing capacity of material can be fully considered.
Guangsi Zhao, Minghui Ren, Xianhao Qiu, Qinghua Xue   +3 more
doaj   +1 more source

Stability Analysis of Roadway in Weakly Consolidated Formation Based on Clay Mineral Content

Meikuang Anquan, 2020
Taking Wujianfang west No.1 mine in Inner Mongolia as the engineering background, XRD mineral diffraction analysis, combined determination of liquid-plastic limit and laboratory mechanical test were carried out on three groups of weakly consolidated soft
ZHAO Weisheng, LIANG Wei, XU Mengtang, LIU Bin
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source