Results 71 to 80 of about 14,949 (262)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Shakedown and limit analysis of 90° pipe bends under internal pressure, cyclic in-plane bending and cyclic thermal loading

open access: yes, 2011
The Linear Matching Method is used to create the shakedown limit and limit load interaction curves of 90 degree pipe bends for a range of bend factors.
Ure, James Michael   +9 more
core   +1 more source

Effect of pH value on boundary water content of red clay in Guilin and its mechanism

open access: yesYantu gongcheng xuebao, 2017
The liquid and plastic limits are the important factors to reflect the penetration resistance, anti-erosion and anti-shear of soils. The liquid ad plastic limits of the red clay in Guilin soaked in the acid and alkali solutions are tested to study its ...
LI Shan-mei 1,2, LIU Zhi-kui 1,2, MENG Jian-ping 1,2
doaj   +1 more source

Limits to behavioural plasticity

open access: yesGlobal Change Biology, 2023
Larissa T. Beumer, Thomas Mueller
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

NOVEL NUMERICAL PROCEDURES FOR LIMIT ANALYSIS OF STRUCTURES: MESH-FREE METHODS AND MATHEMATICAL PROGRAMMING [PDF]

open access: yes, 2010
Current research in the field of limit analysis is focussing on the development of numerical tools which are sufficiently efficient and robust to be used in engineering practice.
Le, Canh
core  

A fully implicit, lower bound, multi-axial solution strategy for direct ratchet boundary evaluation : theoretical development

open access: yes, 2013
Ensuring sufficient safety against ratchet is a fundamental requirement in pressure vessel design. Determining the ratchet boundary can prove difficult and computationally expensive when using a full elastic-plastic finite element analysis and a number ...
Jappy, Alan   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Influence of Inorganic Salts on Soils Liquid and Plastic Limits

open access: yesCivil Engineering Dimension, 2013
This study focused on the influence of inorganic salts on soil liquid limit (LL) and plastic limit (PL). Sodium chloride, NaCl, potassium nitrate KNO3 and calcium sulphate, CaSO4 of various concentrations were added to two subsoils.
Ayininuola, G.M., Agbede, O.A.
doaj  

Prediction of Consolidation Characteristics from Index Properties

open access: yesE3S Web of Conferences, 2018
Compression index and coefficient of consolidation are two most important parameters in obtaining the consolidation characteristics of cohesive soil. Considerable time and effort are required to obtain these parameters from the oedometer test. Therefore,
Ng Kok Shien   +2 more
doaj   +1 more source

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