Results 91 to 100 of about 14,949 (262)

Calculation of a lower bound ratchet limit part 1 – Theory, numerical implementation and verification

, 2013
It is important to be able to calculate the ratchet limit of a component when performing integrity assessments of plant components. This paper details the addition of a lower bound ratchet limit calculation to the Linear Matching Method. The extension of
Tipping, David, Ure, James Michael, Chen, Haofeng   +2 more
core   +1 more source

Analysis of elasto-plastic deformations of thick cylindrical tubes subject to pressures

MATEC Web of Conferences, 2014
This work consist in determining and analyzing analytically the stress and elasto-plastic strain state including the limit state using the theory of Huber-Mises-Henkey and formulating mathematically and solving the problem of determination of shearing ...
Rouabhi A.
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Integrated structural analysis tool using linear matching method part 2 : Application and verification

, 2014
In an accompanying paper, a new integrated structural analysis tool using the LMM framework for the assessment of design limits in plasticity including load carrying capacity, shakedown limit, ratchet limit and steady state cyclic response of structures ...
Tipping, David, Chen, Haofeng, Ure, James   +2 more
core   +1 more source

On the ratchet analysis of a cracked welded pipe [PDF]

, 2011
This paper presents the ratchet limit analysis of a pipe with a symmetric crack in a mismatched weld by using the extended Linear Matching Method (LMM). Two loading conditions are considered: i) a cyclic temperature load and a constant internal pressure;
Ure, James Michael, James Ure, Haofeng Chen, Chen, Haofeng, Li, Tianbai, Tianbai Li, Weihang Chen, Chen, Weihang   +7 more
core   +1 more source

Optimization of glass debris in the treatment of swelling clay soils using recycled materials for sustainable road engineering

Scientific Reports
This study focuses on the valorization of glass waste in the field of geotechnics, particularly for the reinforcement of clay soils used in road construction. Glass waste, produced in large quantities, represents a potentially sustainable resource.
Noureddine Ouslimane, Jaouad Bensalah, Hanane Barebita, Mohammad K. Okla, Samir Ibenmoussa, Youssouf Ali Younous, Fouad Dimane, Mustapha Belfaquir   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Parametric plastic collapse loads and their validation for horizontal saddle supported storage vessels

, 2003
In general, progressive plastic collapse occurs in vessels with low values of R/t ratio, typically less than 200, and elastic-plastic buckling is observed in vessels with higher R/t ratios. The aim of this paper is to examine various theoretical analyses
Spence, J., Nash, D.H.
core