Results 101 to 110 of about 14,949 (262)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Design by analysis of ductile failure and buckling in torispherical pressure vessel heads

, 2007
Thin shell torispherical pressure vessel heads are known to exhibit complex elastic-plastic deformation and buckling behaviour under static pressure. In pressure vessel Design by Analysis, the designer is required to assess both of these behaviour modes ...
Camilleri, Duncan, Hamilton, Robert, Mackenzie, Donald   +2 more
core   +1 more source

Strain localization analysis using a multiscale model [PDF]

, 2007
In order to analyze the formability of steels in sheet metal forming, a ductility loss criterion is coupled with a multiscale model. The behavior at the mesoscopic (grain) scale is modeled by a large strain micromechanical constitutive law, which is then
LEMOINE, Xavier, BERVEILLER, Marcel, ABED-MERAIM, Farid, FRANZ, Gérald, BEN ZINEB, Tarak   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The linear matching method applied to the high temperature life integrity of structures. Part 1. Assessments involving constant residual stress fields

, 2006
Design and life assessment procedures for high temperatures are based on 'expert knowledge' in structural mechanics and materials science, combined with simplified methods of structural analysis. Of these R5 is one of the most widely used life assessment
Chen, Haofeng, Ponter, Alan R.S., Ainsworth, R.A.   +2 more
core   +1 more source

Effect of specimen size on true stress-true strain relationship up to the plastic deformation limit in ultrafine-grained ferrite-cementite steels

Nihon Kikai Gakkai ronbunshu, 2017
The effect of specimen size on tensile deformation behavior of the ultrafine-grained ferrite-cementite (FC) steel was studied from the viewpoint of true stress (σ)-true strain (ε) relationship.
Noriyuki TSUCHIDA, Syuhei UENO, Tadanobu INOUE   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The optimal location of the polygonal internal supports to the circular rigid-plastic plates

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014
The general solution of a problem of the limit behavior and dynamic bend is obtained for the perfect rigid-plastic circular plates, hinge supported on immobile polygonal contour, located inside the plate. The plate is subjected to short-term dynamic load
Tatiana P Romanova
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A fully implicit multi-axial solution strategy for direct ratchet boundary evaluation : implementation and comparison

, 2012
Ensuring sufficient safety against ratcheting is a fundamental requirement in pressure vessel design. However, determining the ratchet boundary using a full elastic plastic finite element analysis can be problematic and a number of direct methods have ...
Jappy, Alan, Chen, Haofeng, Mackenzie, Donald   +2 more
core