Results 31 to 40 of about 419,145 (267)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Journal of Materials Research and Technology, 2019 The cyclic plastic deformation of an archetypal microstructure dual phase steels has been examined via micromechanics modelling based on representative volume elements technique.
Amit Kumar Rana +2 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
EPJ Web of Conferences, 2010 Plastic deformation causes very small changes in the thermoelastic response of metallic materials; this variation of the thermoelastic constant has the potential to form the basis of a new non-destructive, non-contact, full-field technique for ...
Quinn S. +3 more
doaj +1 more source
Evaluation of Damage Index for RC Frames with Irregular Geometrical Shape Subjected to Blast Loads
Tikrit Journal of Engineering Sciences, 2020 The present research focuses on studying the effect of architectural shape of reinforced concrete frames resulting from irregularity of geometrical shape of building frame.
Riyadh M. M. Alaaraji +1 more
doaj +1 more source
Competition alters species’ plastic and genetic response to environmental change
Scientific Reports, 2021 Species react to environmental change via plastic and evolutionary responses. While both of them determine species’ survival, most studies quantify these responses individually.
Lynn Govaert +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Asymmetric Response of a Jammed Plastic Bead Raft [PDF]
Physical Review Letters, 2006 Fluctuation-dissipation relations have received significant attention as a potential method for defining an effective temperature in nonequilibrium systems. The successful development of an effective temperature would be an important step in the application of statistical mechanics principles to systems driven far from equilibrium.
Twardos, Michael, Dennin, Michael
openaire +3 more sources
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source