Results 181 to 190 of about 26,050 (260)

Pharmacokinetic Tuning Redirects β‐Lapachone From NQO1 Bioactivation to Vimentin‐Targeted Oxidation in Cancer

open access: yesAdvanced Science, EarlyView.
Pharmacokinetic tuning acts as a programmable mechanistic switch for β‐lap. Sustained low‐concentration exposure redirects β‐lap from NQO1 bioactivation to direct oxidation of vimentin, driving disulfide crosslinking, proteasomal overload and ferroptosis.
Lei Dou   +5 more
wiley   +1 more source

Spray‐Dried mRNA‐LNP Powder Enabling Multi‐Route Delivery With 3‐Year Refrigerated Stability

open access: yesAdvanced Science, EarlyView.
Spray‐dried mRNA‐LNP powder with trehalose matrix enables reconstitution for parenteral delivery or direct administration via pulmonary and sublingual routes, maintaining protein expression comparable to liquid controls. The thermostable powder preserves colloidal stability, mRNA integrity, and biological activity for over 3 years at 2°C–8°C, while ...
Ashish Sarode   +4 more
wiley   +1 more source

Creep Modeling and Influencing Factor Analysis of Ultradeep Salt Cavern Gas Storage. [PDF]

open access: yesACS Omega
Su Y   +7 more
europepmc   +1 more source

Exfoliated‐MoS2 Gradual Resistive Switching Devices as Artificial Synapses

open access: yesAdvanced Electronic Materials, EarlyView.
A vertical memristor based on untreated, exfoliated MoS2 is presented, revealing gradual resistive switching governed by Schottky barrier modulation at the MoS2/metal interface from the trapping/detrapping of charges. Furthermore, the device emulates synaptic‐like plasticity functions, including: potentiation, depression, and spike‐amplitude‐dependent ...
Deianira Fejzaj   +3 more
wiley   +1 more source

Bridging Performance and Fate: A Framework for Sustainable, Composite‐Based Flexible Electronic Systems

open access: yesAdvanced Electronic Materials, EarlyView.
Composite‐based flexible electronics integrate biodegradable polymers, conductive networks, and multilayer device architectures to balance electrical performance, mechanical durability, and controlled degradation. Interfacial engineering and encapsulation regulate transport stability and operational lifetime, while programmed disassembly enables ...
Sayam, Sangho Cho
wiley   +1 more source

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