Results 31 to 40 of about 233,575 (267)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Heat Transfer and Thermo-Mechanical Analysis of Plastic-Strain Evolution in Laser-Welded Thin-Walled Laminated Cooling Plates with Non-Uniform Stiffness

Energies
Thin-walled laminated cooling plates integrate internal channels and pin-fin cores, producing reduced and spatially non-uniform stiffness that changes welding restraint and distortion. This study investigates stiffness-controlled plastic-strain evolution
Chengkun Li, Yujia Cai, Han Wang, Zhihang Zhang, Fang Han, Xiaoqing Zhu, Chengcheng Wang, Zhibo Dong   +7 more
doaj   +1 more source

Plastic deformation behavior and constitutive modeling of Cu-50Ta alloy during hot compression

Materials Research Express, 2022
This paper presents a study on plastic deformation behavior of Cu–50Ta alloy at temperatures of 286–473 K and strain-rate of 0.01–6200 s ^−1 . The effects of temperature, strain-rate, and strain on the yield strength, flow stress, and strain-rate ...
Bo Pu, Ping Song, Wen-Bin Li, Wen-Jin Yao, Xiao-Ming Wang   +4 more
doaj   +1 more source

Quasistatic Nonassociative Plasticity at Finite Strains

Journal of Nonlinear Science
We investigate finite-strain elastoplastic evolution in the nonassociative setting. The constitutive material model is formulated in variational terms and coupled with the quasistatic equilibrium system. We introduce measure-valued energetic solutions and prove their existence via a time discretization approach.
Stefanelli, Ulisse, Vikelis, Andreas
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Multifield finite strain plasticity: Theory and numerics

Computer Methods in Applied Mechanics and Engineering, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Karol Lewandowski, Daniele Barbera, Paul Blackwell, Amir H. Roohi, Ignatios Athanasiadis, Andrew McBride, Paul Steinmann, Chris Pearce, Łukasz Kaczmarczyk   +8 more
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source