Results 41 to 50 of about 657,951 (302)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Numerical modeling of strain rate hardening effects on viscoplastic behavior of metallic materials [PDF]

, 2017
The main goal of the present work is to provide a finite strain elasticviscoplastic framework to numerically account for strain, strain rate hardening, and viscous effects in cold deformation of metallic materials. The aim is to provide a simple and robust
Dos Santos, Tiago, Maghous, Samir, Rosa, Pedro A. R., Rossi, Rodrigo   +3 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Strain Gradient Plasticity Analysis of Amorphous Plasticity

Procedia Structural Integrity
Amorphous materials lack a defined crystalline structure, exhibiting a disordered atomic arrangement that imparts superb mechanical properties and great potential for applications in many areas. Because of their disordered nature, metallic glasses exhibit dramatically different deformation behaviours than crystalline materials.
Ünsal, İzzet Erkin, Yalçınkaya, Tuncay   +1 more
openaire   +3 more sources

Heat Transfer and Thermo-Mechanical Analysis of Plastic-Strain Evolution in Laser-Welded Thin-Walled Laminated Cooling Plates with Non-Uniform Stiffness

Energies
Thin-walled laminated cooling plates integrate internal channels and pin-fin cores, producing reduced and spatially non-uniform stiffness that changes welding restraint and distortion. This study investigates stiffness-controlled plastic-strain evolution
Chengkun Li, Yujia Cai, Han Wang, Zhihang Zhang, Fang Han, Xiaoqing Zhu, Chengcheng Wang, Zhibo Dong   +7 more
doaj   +1 more source

Plastic deformation behavior and constitutive modeling of Cu-50Ta alloy during hot compression

Materials Research Express, 2022
This paper presents a study on plastic deformation behavior of Cu–50Ta alloy at temperatures of 286–473 K and strain-rate of 0.01–6200 s ^−1 . The effects of temperature, strain-rate, and strain on the yield strength, flow stress, and strain-rate ...
Bo Pu, Ping Song, Wen-Bin Li, Wen-Jin Yao, Xiao-Ming Wang   +4 more
doaj   +1 more source

Plastic deformations in mechanically strained single-walled carbon nanotubes [PDF]

, 2003
Antiferromagnetic manipulation was used to controllably stretch individual metallic single-walled carbon nanotubes (SWNT's). We have found that SWNT's can sustain elongations as great as 30% without breaking.
Bockrath, M., Bozovic, Dolores, Hafner, Jason H., Lieber, Charles M., Park, Hongkun, Tinkham, M.   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Determination of plasticity following deformation and welding of austenitic stainless steel [PDF]

, 2017
Intergranular strain has been associated with high-temperature cracking of welded pipework in 316H austenitic stainless steel material used in nuclear power plant heat exchangers.
Acar, Murat O., Fitzpatrick, Michael E.
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source