Results 11 to 20 of about 1,298,913 (269)
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Science, 2022 Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage
J. Chan +26 more
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Journal of Medical Case Reports, 2022 Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable.
Andrea Giorni +5 more
doaj +1 more source
Developmental Cell, 2013 Pancreas homeostasis is based on replication of differentiated cells in order to maintain proper organ size and function under changing physiological demand. Recent studies suggest that acinar cells, the most abundant cell type in the pancreas, are facultative progenitors capable of reverting to embryonic-like multipotent progenitor cells under injury ...
Oren Ziv, Benjamin Glaser, Yuval Dor
openaire +3 more sources
British Journal of Cancer, 2021 Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome.
Fabiana Lüönd +2 more
semanticscholar +1 more source
Microglia regulation of synaptic plasticity and learning and memory
Neural Regeneration Research, 2021 Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and ...
J. Cornell +3 more
semanticscholar +1 more source
Tool use induces complex and flexible plasticity of human body representations [PDF]
, 2012 Plasticity of body representation fundamentally underpins human tool use. Recent studies have demonstrated remarkably complex plasticity of body representation in humans, showing that such plasticity: (1) occurs flexibly across multiple time-scales, and (
Longo, Matthew R., Serino, A.
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Macrophage plasticity and polarization: in vivo veritas.
Journal of Clinical Investigation, 2012 Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes ...
A. Sica, A. Mantovani
semanticscholar +1 more source
Plasticity of Inhibition [PDF]
Neuron, 2012 Until recently, the study of plasticity of neural circuits focused almost exclusively on potentiation and depression at excitatory synapses on principal cells. Other elements in the neural circuitry, such as inhibitory synapses on principal cells and the synapses recruiting interneurons, were assumed to be relatively inflexible, as befits a role of ...
DimitriýM. Kullmann +3 more
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Physical but not virtual presence of others potentiates implicit and explicit learning
Scientific Reports, 2022 E-learning activities are becoming more and more common. Whilst it is well known that the physical presence of others motivates individuals to engage in perceptual and learning tasks, systematic investigations comparing the effects of physical and ...
Pietro Sarasso +8 more
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Endochronic theory, non-linear kinematic hardening rule and generalized plasticity: a new interpretation based on generalized normality assumption [PDF]
, 2005 A simple way to define the flow rules of plasticity models is the assumption of generalized normality associated with a suitable pseudo-potential function.
Auricchio +35 more
core +7 more sources