Results 11 to 20 of about 1,472,006 (329)
Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Signal Transduction and Targeted Therapy, 2023 Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity ...
Zhenjun Shi +8 more
semanticscholar +1 more source
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Science, 2022 Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage
J. Chan +26 more
semanticscholar +1 more source
Diversity, Mechanisms, and Significance of Macrophage Plasticity.
Annual Review of Pathology, 2020 Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow-derived cells); the organ context; the activation or deactivation of various signals in ...
M. Locati, G. Curtale, A. Mantovani
semanticscholar +1 more source
Crystals, 2021 The Special Issue on “Crystal Plasticity” is a collection of 25 original articles (including one review paper) dedicated to theoretical and experimental research works providing new insights and practical findings in the field of crystal plasticity ...
W. Polkowski
semanticscholar +1 more source
Root plasticity under abiotic stress
Plant Physiology, 2021 Abiotic stresses increasingly threaten existing ecological and agricultural systems across the globe. Plant roots perceive these stresses in the soil and adapt their architecture accordingly.
R. Karlova +3 more
semanticscholar +1 more source
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core +1 more source
British Journal of Cancer, 2021 Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome.
Fabiana Lüönd +2 more
semanticscholar +1 more source
Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit
Frontiers in Synaptic Neuroscience, 2016 The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Luke Yuri Prince +3 more
doaj +1 more source
Microglia regulation of synaptic plasticity and learning and memory
Neural Regeneration Research, 2021 Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and ...
J. Cornell +3 more
semanticscholar +1 more source
Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication
eLife, 2021 Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced ...
Neale J Harrison +8 more
doaj +1 more source