Journal of Neuroinflammation, 2020 Background Early-life stress (ES) is an emerging risk factor for later life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model ...
Maralinde R. Abbink +7 more
doaj +1 more source
Whole-brain tracking of cocaine and sugar rewards processing
Translational Psychiatry, 2023 Natural rewards, such as food, and sex are appetitive stimuli available for animals in their natural environment. Similarly, addictive rewards such as drugs of abuse possess strong, positive valence, but their action relies on their pharmacological ...
Łukasz Bijoch +7 more
doaj +1 more source
GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors
iScience, 2023 Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored.
Jithin D. Nair +6 more
doaj +1 more source
Effects of Synaptic and Myelin Plasticity on Learning in a Network of Kuramoto Phase Oscillators [PDF]
, 2019 Models of learning typically focus on synaptic plasticity. However, learning is the result of both synaptic and myelin plasticity. Specifically, synaptic changes often co-occur and interact with myelin changes, leading to complex dynamic interactions ...
D. Dibenedetto +10 more
core +2 more sources
Direct and indirect selection on flowering time, water-use efficiency (WUE, δ (13)C), and WUE plasticity to drought in Arabidopsis thaliana. [PDF]
, 2014 Flowering time and water-use efficiency (WUE) are two ecological traits that are important for plant drought response. To understand the evolutionary significance of natural genetic variation in flowering time, WUE, and WUE plasticity to drought in ...
Juenger, Thomas E +3 more
core +1 more source
Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth
eLife, 2014 Endocannabinoids are recently recognized regulators of brain development, but molecular effectors downstream of type-1 cannabinoid receptor (CB1R)-activation remain incompletely understood.
Alexandre B Roland +10 more
doaj +1 more source
Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]
, 2012 A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T. +12 more
core +2 more sources
Uncoupled material model of ductile fracture with directional plasticity [PDF]
, 2017 Proposed paper deals with the application of plastic response with directional distortional hardening (DDH) in uncoupled ductile fracture model and comparison of the results with the same ductile fracture model based on isotropic J2 plasticity.
Dzugan, Jan +4 more
core
, 2005 A Phenomenological Mesoscopic Field Dislocation Mechanics (PMFDM) model is developed, extending continuum plasticity theory for studying initial-boundary value problems of small-scale plasticity.
Acharya, Amit, Roy, Anish
core +1 more source
Spiking Neural Networks for Inference and Learning: A Memristor-based Design Perspective [PDF]
, 2019 On metrics of density and power efficiency, neuromorphic technologies have the potential to surpass mainstream computing technologies in tasks where real-time functionality, adaptability, and autonomy are essential.
Abbott +56 more
core +2 more sources