Maladaptive plasticity in levodopa-induced dyskinesias and tardive dyskinesias: old and new insights on the effects of dopamine receptor pharmacology. [PDF]
, 2014 Maladaptive plasticity can be defined as behavioral loss or even development of disease symptoms resulting from aberrant plasticity changes in the human brain.
Ahmed +58 more
core +2 more sources
The conceptual structure of evolutionary biology: A framework from phenotypic plasticity [PDF]
, 2018 In this review, I approach the role of phenotypic plasticity as a key aspect of the conceptual framework of evolutionary biology. The concept of phenotypic plasticity is related to other relevant concepts of contemporary research in ...
Martins, Rogerio P
core +2 more sources
Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice
Translational Psychiatry, 2021 Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice.
Daniel E. Heinz +6 more
doaj +1 more source
Balancing noise and plasticity in eukaryotic gene expression [PDF]
, 2012 Coupling the control of expression stochasticity (noise) to the ability of expression change (plasticity) can alter gene function and influence adaptation.
Bajić, Djordje, Poyatos, Juan F.
core +4 more sources
Foraging environment determines the genetic architecture and evolutionary potential of trophic morphology in cichlid fishes [PDF]
, 2016 Phenotypic plasticity allows organisms to change their phenotype in response to shifts in the environment. While a central topic in current discussions of evolutionary potential, a comprehensive understanding of the genetic underpinnings of plasticity is
Albertson, R. Craig +7 more
core +2 more sources
GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors
iScience, 2023 Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored.
Jithin D. Nair +6 more
doaj +1 more source
Whole-brain tracking of cocaine and sugar rewards processing
Translational Psychiatry, 2023 Natural rewards, such as food, and sex are appetitive stimuli available for animals in their natural environment. Similarly, addictive rewards such as drugs of abuse possess strong, positive valence, but their action relies on their pharmacological ...
Łukasz Bijoch +7 more
doaj +1 more source
Effects of Synaptic and Myelin Plasticity on Learning in a Network of Kuramoto Phase Oscillators [PDF]
, 2019 Models of learning typically focus on synaptic plasticity. However, learning is the result of both synaptic and myelin plasticity. Specifically, synaptic changes often co-occur and interact with myelin changes, leading to complex dynamic interactions ...
D. Dibenedetto +10 more
core +2 more sources
Journal of Neuroinflammation, 2020 Background Early-life stress (ES) is an emerging risk factor for later life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model ...
Maralinde R. Abbink +7 more
doaj +1 more source
Loss of plasticity in deep continual learning
NatureArtificial neural networks, deep-learning methods and the backpropagation algorithm1 form the foundation of modern machine learning and artificial intelligence.
Shibhansh Dohare +5 more
semanticscholar +1 more source