Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex
eLife, 2016 The spatial organization of synaptic inputs on the dendritic tree of cortical neurons plays a major role for dendritic integration and neural computations, yet, remarkably little is known about it.
Onur Gökçe +2 more
doaj +1 more source
Fluctuating population dynamics promotes the evolution of phenotypic plasticity [PDF]
, 2007 An increasing number of studies are showing evidence in support of sympatric speciation. One basic question remains, however. When a population has undergone a branching in its phenotype, is this due to an evolutionary branching in the underlying ...
Mario Pineda-Krch +2 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BMC PsychiatryBackground Panic disorder (PD) significantly impacts individuals’ daily lives and overall well-being. While cognitive behavioral therapy (CBT) is the gold standard for PD treatment, there is a growing interest in brief interventions to improve ...
Bjarne Hansen +4 more
doaj +1 more source
Control over stress induces plasticity of individual prefrontal cortical neurons: A conductance-based neural simulation [PDF]
, 2011 Behavioral control over stressful stimuli induces resilience to future conditions when control is lacking. The medial prefrontal cortex(mPFC) is a critically important brain region required for plasticity of stress resilience.
Andrew L. Varnell +3 more
core +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Long-term follow-up of the Bergen 4-day treatment for panic disorder during the COVID-19 pandemic
Cogent PsychologyThe COVID-19 pandemic has necessitated essential modifications to the administration of psychotherapy for patients with panic disorder (PD) through the increased use of videoconferencing.
Kay Morten Hjelle +7 more
doaj +1 more source
LRP4 is required for the olfactory association task in the piriform cortex
Cell & Bioscience, 2022 Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan +12 more
doaj +1 more source
Temporal nature of plasticity in the design of materials [PDF]
, 2019 A full spectrum of materials responses to dynamic loading and observed temporal effects of plasticity from a united viewpoint are analyzed. The relaxation model of plasticity with characteristic time idea is capable to effectively predict the instability
Petrov, Y. V., Selyutina, N. S.
core
Excitation spectra in crystal plasticity [PDF]
, 2017 Plastically deforming crystals exhibit scale-free fluctuations that are similar to those observed in driven disordered elastic systems close to depinning, but the nature of the yielding critical point is still debated.
Alava, Mikko J. +4 more
core +2 more sources