Results 41 to 50 of about 6,952,969 (304)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Eurasian Physical Technical JournalA unified analytical framework is developed to describe the deformation resistance of metals under thermoplastic processing conditions. The proposed approach is based on the Hansel-Spittel constitutive equation and establishes a direct relationship ...
S. Sheyko +3 more
doaj +1 more source
Journal of the Mechanical Behavior of Materials, 2016 The gradient plasticity theory proposed by Aifantis and coworkers has been successfully used to model size effect phenomena at the microscale and nanoscale, by introducing into the formulation an internal length scale associated with the phenomenological
Wei Xiaokun +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Crystals, 2020 Rafting is an important phenomenon of the microstructure evolution in nickel-based single crystal superalloys at elevated temperature. Understanding the rafting mechanism and its effect on the microstructure evolution is of great importance in ...
Zhiyuan Yu +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Professor Dyuis D. Ivlev. Dedication to 85th Birtday
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016 Dyuis D. Ivlev (1930-2013) is an outstanding scientist in the fields of Continuum Mechanics (theory of Perfect Plasticity and Fracture) and AppliedMathematics.
Yuri N Radayev, Vladimir P Radchenko
doaj +1 more source
Adaptation, Plasticity, and Extinction in a Changing Environment: Towards a Predictive Theory
PLoS Biology, 2010 The authors analyze developmental, genetic, and demographic mechanisms by which populations tolerate changing environments and discuss empirical methods for determining the critical rate of sustained environmental change that causes population extinction.
Luis‐Miguel Chevin, R. Lande, G. Mace
semanticscholar +1 more source