Results 61 to 70 of about 6,952,969 (304)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Phenotypic plasticity opposes species invasions by altering fitness surface. [PDF]

PLoS Biology, 2006
Understanding species invasion is a central problem in ecology because invasions of exotic species severely impact ecosystems, and because invasions underlie fundamental ecological processes.
Scott D Peacor, Stefano Allesina, Rick L Riolo, Mercedes Pascual   +3 more
doaj   +1 more source

The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus

Journal of Neural Transplantation and Plasticity, 2013
Depression is a devastating and prevalent disease, with profound effects on neural structure and function; however the etiology and neuropathology of depression remain poorly understood.
S. R. Wainwright, L. Galea
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Spatiotemporal computations of an excitable and plastic brain: neuronal plasticity leads to noise-robust and noise-constructive computations. [PDF]

PLoS Computational Biology, 2014
It is a long-established fact that neuronal plasticity occupies the central role in generating neural function and computation. Nevertheless, no unifying account exists of how neurons in a recurrent cortical network learn to compute on temporally and ...
Hazem Toutounji, Gordon Pipa
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A unified model for cross-modal plasticity and skill acquisition

Frontiers in Neuroscience
Historically, cross-modal plasticity following early blindness has been largely studied in the context of visual deprivation. However, more recently, there has been a shift in focus towards understanding cross-modal plasticity from the perspective of ...
Woon Ju Park, Woon Ju Park, Ione Fine, Ione Fine   +3 more
doaj   +1 more source

Deep learning predicts path-dependent plasticity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance We show that material plasticity can be precisely and efficiently predicted by deep-learning methods. This approach is fundamentally different from the century-old theory of continuum plasticity because it is not iteratively tracing the ...
M. Mozaffar, R. Bostanabad, R. Bostanabad, Wei Chen, K. Ehmann, Jian Cao, M. Bessa   +6 more
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The influence of James and Darwin on Cajal and his research into the neuron theory and evolution of the nervous system

Frontiers in Neuroanatomy, 2014
In this article we discuss the influence of William James and Charles Darwin on the thoughts of Ramón y Cajal concerning the structure, plasticity and evolution of the nervous system at the cellular level.
Francisco Rômulo Monte Ferreira, Maria Inês Nogueira, Javier eDeFelipe   +2 more
doaj   +1 more source