Results 71 to 80 of about 18,342 (267)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Preparation and characterization of PVC/PMMA blend polymer electrolytes complexed with LiN(C2F5SO2)2

Polímeros, 2004
Thin films of polymer blend electrolytes comprising Poly(vinyl chloride) (PVC) and Poly(methyl methacrylate)(PMMA) and plasticized with a combination of ethylene carbonate (EC) and propylene carbonate (PC) for different lithium imide salt, LiN(C2F5SO3)2 ,
R. Nimma Elizabeth, S. Kalyanasundaram, A. Gopalan, Y. Saito, A. Manuel Stephan   +4 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effect of Plasticizer Type on Properties, Structure and Application Effect of Pullulan-Soluble Soybean Polysaccharide Film

Shipin gongye ke-ji
In order to improve the flexibility and heat-sealing performance of pullulan-soluble soybean polysaccharide film and its application potential, the effects of four plasticizers (polyethylene glycol, propylene glycol, glycerol and sorbitol) on the ...
Fan ZHAO, Lijun JIANG, Shuangdie LI, Chenyu WANG, Di SUN, Yu LIU, Wei JIANG   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Measuring Degree of Contamination by Semi-volatile Organic Compounds (SVOC) in Interiors of Korean Homes and Kindergartens

Journal of Asian Architecture and Building Engineering, 2017
PVC floor material is widely used in Korean homes, and people customarily sit or lie on the floor surface. This could potentially put residents of such homes at high risk of exposure to semi-volatile organic compounds (SVOCs). However, there is a current
Hyun-tae Kim, Shin-ichi Tanabe
doaj   +1 more source

Caracterização mecânica e térmica de compósitos de poli (cloreto de vinila) reforçados com fibras de sisal Mechanical and thermal characterization of the polyvinyl chloride-sisal fibers composites

Polímeros, 2004
Compósitos de PVC, plastificados com diferentes sistemas de plastificação e reforçados com fibras de sisal, foram processados em moinho de dois rolos. A influência do tipo e teor do plastificante, do comprimento e do teor das fibras nas propriedades dos ...
Gilson S. Martins, Marco A. Iozzi, Maria A. Martins, Luiz H. C. Mattoso, Fábio C. Ferreira   +4 more
doaj   +1 more source