Results 121 to 130 of about 770,781 (351)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Exploring the molecular mechanisms of phthalates in the comorbidity of preeclampsia and depression by integrating multiple datasets

Frontiers in Psychiatry
IntroductionPreeclampsia (PE) and depressive disorder (DD) exhibit clinical comorbidity, yet the molecular mechanisms underlying this association remain poorly understood.MethodsDifferential expression analysis of placental and peripheral blood ...
Xinpeng Tian, Xia Gu, Yuecheng Yuan, Yaqiong Zhang, Yantuanjin Ma, Yantuanjin Ma, Yingliang Liu, Yingliang Liu   +7 more
doaj   +1 more source

Synthesis and properties of castor oil based plasticizers

RSC Advances, 2019
A series of environment-friendly plasticizers has been synthesized from castor oil through a mild esterification/epoxidation reaction. The modified epoxy acetylated castor oil (EACO) can plastify poly(vinyl chloride) (PVC) efficiently, even better than ...
Qinghe Fu, Yilang Long, Yingyun Gao, Yuan Ling, Hao Qian, F. Wang, Xinbao Zhu   +6 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Processing and structure-property relationships of natural rubber/wheat bran biocomposites [PDF]

, 2016
In this work, wheat bran was used as cellulosic filler in biocomposites based on natural rubber. The impact of wheat bran content [ranging from 10 to 50 parts per hundred rubber (phr)] on processing, structure, dynamic mechanical properties, thermal ...
Colom Fajula, Xavier, Formela, Krzysztof, Hejna, Aleksander, Piszczyk, Lukasz, Reza Saeb, Mohammad   +4 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Influence of Plasticizers Honey and Glycerol on the Properties of Membranes Based on Babassu Coconut Mesocarp [PDF]

Materials Research
This study developed membranes based on babassu coconut mesocarp and evaluated the impact of honey (80% w/w – MM80 and 100% w/w – MM100) and glycerol (30% w/w – MG30 and 40% w/w – MG40) as plasticizers on their mechanical properties, wetting, and ...
Emanuella de Araújo Carvalho, Bianca Sthefany Souza Pinheiro, Douglas Thainan Silva Lima Mendes, Valdeci Bosco dos Santos, Débora dos Santos Tavares, Cristiane Xavier Resende   +5 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source