Results 41 to 50 of about 66,365 (223)
Neuron, 2013 Although circadian clocks normally run with a 24 hr period, Brancaccio et al. (2013) report in this issue of Neuron that transiently activating G protein signaling can lengthen period even after the stimulus is removed, revealing an unexpected plasticity in the central brain clock.
Ben Collins, Justin Blau
openaire +3 more sources
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Knot Theory and the Problem of Classification for Plastic State [PDF]
arXiv, 1999 In this paper we constructed new model of plastic deformation. The knot theory was used to classify the plastic state.
arxiv
Non-local fractional model of rate independent plasticity [PDF]
, 2013 In the paper the generalisation of classical rate independent plasticity using fractional calculus is presented. This new formulation is non-local due to properties of applied fractional differential operator during definition of kinematics. In the description small fractional strains assumption is hold together with additive decomposition of total ...
arxiv +1 more source
The Plasticity of Mimesis [PDF]
MLN, 2017 This article inscribes Catherine Malabou's recent philosophical account of brain plasticity in a genealogy that goes, from Lacoue-Labarthe, back to its mimetic origins in Plato's Republic. Este artículo inscribe el reciente relato filosófico de Catherine Malabou sobre la plasticidad cerebral en una genealogía que se remonta, desde Lacoue-Labarthe, a ...
openaire +4 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Differentiable plasticity: training plastic neural networks with backpropagation [PDF]
Proceedings of the 35th International Conference on Machine
Learning (ICML2018), Stockholm, Sweden, PMLR 80, 2018, 2018 How can we build agents that keep learning from experience, quickly and efficiently, after their initial training? Here we take inspiration from the main mechanism of learning in biological brains: synaptic plasticity, carefully tuned by evolution to produce efficient lifelong learning.
arxiv
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger +2 more
wiley +1 more source
Quasistatic evolution for dislocation-free finite plasticity [PDF]
arXiv, 2019 We investigate quasistatic evolution in finite plasticity under the assumption that the plastic strain is compatible. This assumption is well-suited to describe the special case of dislocation-free plasticity and entails that the plastic strain is the gradient of a plastic deformation map.
arxiv