Results 91 to 100 of about 3,860,038 (286)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Stress analysis and fatigue life prediction of a wobble-plate [PDF]
, 2006 A five-stage compressor for compressing natural gas is being designed and evaluated. The compressor operates at 1500 rpm with natural gas pressure of 50 psi.
Osman Ali, Hassan
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Propagating plane harmonic waves through finite length plates of variable thickness using finite element techniques [PDF]
, 1983 An analysis is given using finite element techniques which addresses the propagaton of a uniform incident pressure wave through a finite diameter axisymmetric tapered plate immersed in a fluid.
Clark, J. H. +2 more
core +1 more source
Casimir densities for a plate in de Sitter spacetime
, 2009 Wightman function, the vacuum expectation values of the field squared and the energy-momentum tensor are investigated for a scalar field with general curvature coupling parameter in the geometry of a plate in the de Sitter spacetime.
Saharian, A. A., Vardanyan, T. A.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Dissemination of shock waves in thin isotropic plates
MATEC Web of Conferences, 2019 The article deals with the propagation of shock waves in thin isotropic plates. The solution is done analytically. The geometric model of Kirchhoff and Rayleigh was used for the solution. Material model was used Hook.
Klimenda František +3 more
doaj +1 more source
Origins of the avian neural crest: the role of neural plate-epidermal interactions [PDF]
, 1995 We have investigated the lineage and tissue interactions that result in avian neural crest cell formation from the ectoderm. Presumptive neural plate was grafted adjacent to non-neural ectoderm in whole embryo culture to examine the role of tissue ...
Bronner-Fraser, Marianne +1 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source