Results 71 to 80 of about 2,169,057 (252)
Regional distribution of field shale outcrop in China and its shale gas significance
Youqicang pingjia yu kaifa, 2022 In China, shales are widely distributed, continuous in time and complex in space. In this paper, the distribution of shales in the North China, South China and Tarim Plates are systematically sorted out and discussed.
ZHANG Jinchuan +10 more
doaj
The Journal of Engineering Research, 2018 The present paper deals with exact solutions for the free vibration characteristics of thin circular plates resting on Winkler-type elastic foundation based on the classical plate theory elastically restrained against translation.
L.B. Rao, C.K. Rao
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Case Examination of Detection of Structural Damages on a Plate using Wavelet Transform [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2020 Sometimes, suddenly or gradually structural or nonstructural damages are created in structure’s members due to natural or unnatural reasons like earthquake or corrosion. One of the methods used from the early in last decade to recognize damage is wavelet
Ali Mohammad Rousta +3 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 1973 Developments in Geotectonics, 6: Plate Tectonics focuses on the exposition of the plate-tectonics hypothesis, as well as plate boundaries, stratification, and kinematics.
Francheteau, Jean,author. +2 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source