Results 61 to 70 of about 2,894,789 (313)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Novel Approach to the Design of Distributed Dynamic Vibration Absorbers for Plates Subjected to Classical and Elastic Edge Conditions

Journal of Marine Science and Engineering
Plate structures are the main components of offshore platforms and ships in engineering applications. The vibration control of the low-frequency mode of plate structures has always been a meaningful research object in marine science and engineering.
Yuan Du, Yuhang Tang, Chenyu Fan, Yucheng Zou, Zhen Bao, Yong Ma   +5 more
doaj   +1 more source

The Interaction between the Plane Wave and the Plate with Limited Height in Soil [PDF]

Учёные записки Казанского университета: Серия Физико-математические науки, 2017
A solution of the two-dimensional task on interaction between the harmonic wave and the plate with the limited height in soil has been provided. The plate surrounded on both sides with the half-spaces filled with soil medium has been used as a vibro ...
N.A. Lokteva, V.N. Paimushin, D.O. Serdyuk, D.V. Tarlakovskii   +3 more
doaj  

The evolution of plate tectonics

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018
To understand how plate tectonics became Earth's dominant mode of convection, we need to address three related problems. (i) What was Earth's tectonic regime before the present episode of plate tectonics began?
R. Stern
semanticscholar   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Digital Model of Plan View Pattern Control for Plate Mills Based on Machine Vision and the DBO-RBF Algorithm

Metals
Plan view pattern control (PVPC) is a highly effective means to improve the rectangularization of products and increase the yield of plate mills. By optimizing the parameters of PVPC, the effect of PVPC can be further improved.
Zhijie Jiao, Shiwen Gao, Chujie Liu, Junyi Luo, Zhiqiang Wang, Guanyu Lang, Zhong Zhao, Zhiqiang Wu, Chunyu He   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Comparative study on complications of screws versus plates for comminuted radial head and neck fractures with two or three fragments

Frontiers in Surgery
BackgroundThis retrospective study aimed to compare the efficacy of internal fixation using headless compression screws (HCS) and radial head locking plate (RLP) for comminuted radial head and neck fractures with no more than 3 displaced fragments ...
Yuliang Fu, Yuliang Fu, Yuan Cao, Yuan Cao, Zengzhen Cui, Zengzhen Cui, Liangyu Bai, Liangyu Bai, Xiaoyu Norman Pan, Xiaoyu Norman Pan, Yang Lv, Yang Lv   +11 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source